Results 81 to 90 of about 11,769,898 (380)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

E-government and the Electronic Transformation of Modes of Rule: The Case of Partnerships [PDF]

Journal of Systemics, Cybernetics and Informatics, 2004
This paper critically examines some aspects of the discursive and material transformation of government as a result the deployment of the internet and new information technologies.
Paul Henman
doaj  

Social Justice in the EU – Index Report 2016 Social Inclusion Monitor Europe [PDF]

, 2016
1. Social justice in the EU – participation opportunities have improved in the majority of EU member states, but are still a long way behind precrisis levels Social justice has improved slightly in the majority of EU member states compared with last ...
Schiller, Christof, Schraad-Tischler, Daniel   +1 more
core  

SocialDTN: A DTN implementation for Digital and Social Inclusion

, 2013
Despite of the importance of access to computers and to the Internet for the development of people and their inclusion in society, there are people that still suffer with digital divide and social exclusion. Delay/Disruption-Tolerant Networking (DTN) can
Cerqueira, Eduardo, Cirqueira, Douglas, Ferreira, Ronedo, Mendes, Paulo, Moreira, Waldir   +4 more
core   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

The impact of NHS charging regulations on healthcare access and utilisation among migrants in England: a systematic review

BMC Public Health, 2023
Background The NHS Charges to Overseas Visitors Regulations 2015 outline when healthcare costs should be recuperated from overseas visitors in England.
Nazanin Rassa, Margaret McCarthy, Seb Casalotti, Claire Zhang, Fatima Wurie, Colin Brown, Ines Campos-Matos   +6 more
doaj   +1 more source

Neural Correlates of Social Inclusion in Borderline Personality Disorder

Frontiers in Psychiatry, 2018
Humans engage in social interactions and have a fundamental need and motivation to establish and maintain social connections. Neuroimaging studies particularly focused on the neural substrates of social exclusion in healthy subjects (HC), borderline ...
K. Malejko, Dominik Neff, Rebecca Brown, P. Plener, Martina Bonenberger, B. Abler, H. Graf   +6 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

The Observatory on Gender-Based Violence in Bizkaia (OVGB): An Experience of Good Practices

Sortuz, 2017
The Observatory on Gender-based Violence in Bizkaia (OVGB) emerged as an initiative of the Bizkaia Provincial Council (DFB) in 2003. It began to operate in 2004.
Berta Díaz Arbesú
doaj  

Measuring regional social inclusion performances in the EU: Looking for unity in diversity

Journal of European Social Policy, 2018
This study measures and benchmarks regional social inclusion performances in Europe using a composite index constructed on the basis of the commonly agreed sub-indicators of the Europe 2020 headline indicators. The multidimensional nature of these issues
Nicky Rogge, Ryan Self
semanticscholar   +1 more source