Results 101 to 110 of about 1,025,463 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Trends in disability (2001–2019), chronic medical conditions (1996–2020), and mortality (1995–2020) in Japanese older adults: analyses based on national datasets

BMC Geriatrics
Background The overall health status of older adults in Japan has reportedly improved. However, it is unclear whether such improvement has occurred in the baby boomer generation, the oldest of whom turned 65 in 2015.
Hungu Jung, Masahiro Akishita, Shinya Ishii   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Social Inclusion [PDF]

Indian Journal of Human Development, 2013
Uwe Deichmann, Fan Zhang
  +5 more sources

Counting the costs: understanding the extra costs of living with disability in Indonesia to advance inclusive policies within the SDG framework

Frontiers in Rehabilitation Sciences
The Sustainable Development Goals (SDGs) are a multidimensional framework for monitoring progress on disability inclusion over time and among countries where reliable, disability disaggregated data is available.
Irma Marlina, Ginanjar Wibowo, Desi Dwi Bastias, Bimbika Sijapati Basnett, Dinar Dwi Prasetyo, Mercoledi Nasiir   +5 more
doaj   +1 more source

The Challenge of Interdisciplinarity in Operationalizing the Right to Health [PDF]

Health and Human Rights, 2019
Interdisciplinary collaboration between the health and human rights communities is essential to operationalize the right to health. In practice, however, such collaboration has been infrequent.
Gillian MacNaughton, Mariah McGill
doaj  

A social inclusion strategy for Tasmania

, 2009
At the heart of social inclusion – the idea that everyone should have access to the resources and relations that make life healthy, happy and productive – is the importance of strong families and communities, in all their traditional and new forms. 
David Adams
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

When the game turns toxic: Exploring gendered effects on well-being and self-esteem

Computers in Human Behavior Reports
Background: Toxic behavior remains a significant problem in online games, but there is scarce knowledge about the psychological effects of being subjected to such behavior, especially across genders.
Beate Wold Hygen, Stian Lydersen, Daria J. Kuss, Tobias Scholz, Christian Wendelborg   +4 more
doaj   +1 more source

Nueve años de hartz iv: evaluación de una reforma del bienestar

Cuadernos de Relaciones Laborales, 2015
Hace nueve años, Alemania puso en marcha Hartz IV, la última de una serie de reformas del estado social, fusionando en un nuevo y único sistema las antes separadas prestacciones por desempleo de larga duracción y los apoyos a los ingresos.
Markus Promberger
doaj   +1 more source