Results 121 to 130 of about 13,496,740 (294)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
National action plan for social inclusion 2007-2016
, 2007 The commitments set out in this Plan are ambitious and challenging. The new strategic framework will facilitate greater co-ordination and integration of structures and procedures across Government at national and local levels, as well as improved ...
Office for Social Inclusion
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19 Stories of Social Inclusion – Ireland: Stories of Belonging, Contributing and Connecting [PDF]
, 2019 Irish disability policy, in line with international treaties such as the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD), aims to support people with intellectual disabilities to live included lives in their community ...
Murphy, Tomás +6 more
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Relationship between age and ASQ-3 scores for each screening interval in Peruvian infants
Annals of Global Health, 2016 K.C. Chong +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Ethical reflections on the use of the category “children with disabilities” in quantitative research
Frontiers in Rehabilitation SciencesQuantitative research plays a vital role in informing public health policies concerning children with disabilities. However, the categorisation of children as ‘disabled’ in statistical analyses raises complex ethical questions.
Christian Møller-Skau
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A social inclusion strategy for Tasmania
, 2009 At the heart of social inclusion – the idea that everyone should have access to the resources and relations that make life healthy, happy and productive – is the importance of strong families and communities, in all their traditional and new forms.
David Adams
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