Results 141 to 150 of about 1,025,463 (296)
Wacana: Jurnal Sosial dan HumanioraThis research aims to understand how the economic resilience of impoverished female household heads in Jombang Regency can be improved through empowerment programs and to identify strategies that support the implementation of the Female Household Head ...
Alifiulathin Utaminingsih +2 more
doaj +1 more source
National report for Ireland on strategies for social protection and social inclusion: 2008-2010.
, 2008 Following the streamlining of the Open Method of Coordination on Social Protection and Social Inclusion, Member States are now charged with translating the common objectives into National Plans for each of the three areas of Social Inclusion, Pensions ...
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Active Ageing Strategies to Strengthen Social Inclusion : discussion paper. [PDF]
In the coming years, the share of elderly people in the whole population will strongly increase in all European Union countries. It is therefore necessary to implement a social inclusion strategy targeted towards older people both for economic and social
Sterdyniak, Henri
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Promoting social inclusion: More important now than ever?
, 2015 It is indeed a pleasure to bring you this edition of the Journal of Social Inclusion (JoSI) following some recent changes in the Journal’s editorial and support team.
Harris, Paul
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
"Whispers on the wind": social inclusion and the media
, 2011 What is the relationship between the growth and expansion of various forms of the media and chronologically coterminous social movements? This paper deliberately sets out to raise more questions than it attempts to answer.
Chamberlain, Susanna
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source