Results 61 to 70 of about 2,350,942 (296)

Short-term acute outcomes by clinical and socioeconomic characteristics in adults with SARS-CoV-2: a population-based cohort study focused on the first two years of the COVID-19 pandemic

Archives of Public Health
Background The COVID-19 pandemic disproportionately affected vulnerable populations in terms of comorbidity and socioeconomic disadvantage, both between and within countries.
Alice Corsaro, Federico Banchelli, Rossella Buttazzi, Enrico Ricchizzi, Carlo Gagliotti, Elisa Fabbri, Elisa Gentilotti, Maurizia Rolli, Evelina Tacconelli, Maria Luisa Moro, Nicola Caranci, Elena Berti   +11 more
doaj   +1 more source

The current status, challenges, and strategies for high-quality development of the public health system in China

Zhongguo gonggong weisheng
ObjectiveTo systematically evaluate the current status, strengths, and weaknesses of the high-quality development of China’s public health system, and to propose targeted suggestions for improving the system, providing a basis for promoting the high ...
Huihui HUANGFU, Qingyu ZHOU, Huayi ZHANG, Peiyu FENG, Peiwu SHI, Qunhong SHEN, Zhaoyang ZHANG, Zheng CHEN, Chuan PU, Lingzhong XU, Zhi HU, Anning MA, Zhaohui GONG, Tianqiang XU, Panshi WANG, Hua WANG, Chao HAO, Mo HAO, Chengyue LI   +18 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Current status of hypertension management operation mechanisms in Chinese mainland and their impact on prevention and control effects: an analysis on official documents

Zhongguo gonggong weisheng
ObjectiveTo evaluate the current status of hypertension prevention and control management operation mechanisms in Chinese mainland, explore the impact of their improvement on hypertension prevention and control effects, and provide a reference for ...
Huihui HUANGFU, Qinwen YU, Peiwu SHI, Qunhong SHEN, Zhaoyang ZHANG, Zheng CHEN, Chuan PU, Lingzhong XU, Zhi HU, Anning MA, Zhaohui GONG, Tianqiang XU, Panshi WANG, Hua WANG, Chao HAO, Qingyu ZHOU, Mo HAO, Chengyue LI   +17 more
doaj   +1 more source

Health Biotechnology Innovation for Social Sustainability -A Perspective from China [PDF]

, 2011
China is not only becoming a significant player in the production of high-tech products, but also an increasingly important contributor of ideas and influence in the global knowledge economy.
Chen, Yantai, Ely, Adrian
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Innovation and Performance in British-based Manufacturing Industries:Shaping the Policy Agenda [PDF]

, 2002
This paper analyses the relationship between business performance, R&D expenditures and innovation output. It utilises the second Community Innovation Survey (CIS2), a large-scale survey into firms’ innovation activities conducted in the UK by the DTI.
Cox, Howard, Frenz, Marion
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Innovation and social challenges in Catalonia seminar [PDF]

, 2019
Discurs en el Seminari Innovació i reptes socials a Catalunya pronunciat per Josep A. Planell al Palau Macaya, Barcelona.Speech at the Innovation and social challenges in Catalonia seminar pronounced by Josep A.
Planell Estany, Josep A.
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source