Results 61 to 70 of about 326,825 (263)

Capabilities and Didactic Concepts for Social Innovation Education

Diaconia, 2022
This paper presents a conceptual framework of organizational capabilities to develop social innovation in nonprofit organizations. We argue that the development of individual competencies influences and enhances organizational capabilities. Therefore, we
Andreas Schröer, Ione Ardaiz Osacar, Tim Zebahl   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Short-term acute outcomes by clinical and socioeconomic characteristics in adults with SARS-CoV-2: a population-based cohort study focused on the first two years of the COVID-19 pandemic

Archives of Public Health
Background The COVID-19 pandemic disproportionately affected vulnerable populations in terms of comorbidity and socioeconomic disadvantage, both between and within countries.
Alice Corsaro, Federico Banchelli, Rossella Buttazzi, Enrico Ricchizzi, Carlo Gagliotti, Elisa Fabbri, Elisa Gentilotti, Maurizia Rolli, Evelina Tacconelli, Maria Luisa Moro, Nicola Caranci, Elena Berti   +11 more
doaj   +1 more source

The current status, challenges, and strategies for high-quality development of the public health system in China

Zhongguo gonggong weisheng
ObjectiveTo systematically evaluate the current status, strengths, and weaknesses of the high-quality development of China’s public health system, and to propose targeted suggestions for improving the system, providing a basis for promoting the high ...
Huihui HUANGFU, Qingyu ZHOU, Huayi ZHANG, Peiyu FENG, Peiwu SHI, Qunhong SHEN, Zhaoyang ZHANG, Zheng CHEN, Chuan PU, Lingzhong XU, Zhi HU, Anning MA, Zhaohui GONG, Tianqiang XU, Panshi WANG, Hua WANG, Chao HAO, Mo HAO, Chengyue LI   +18 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Current status of hypertension management operation mechanisms in Chinese mainland and their impact on prevention and control effects: an analysis on official documents

Zhongguo gonggong weisheng
ObjectiveTo evaluate the current status of hypertension prevention and control management operation mechanisms in Chinese mainland, explore the impact of their improvement on hypertension prevention and control effects, and provide a reference for ...
Huihui HUANGFU, Qinwen YU, Peiwu SHI, Qunhong SHEN, Zhaoyang ZHANG, Zheng CHEN, Chuan PU, Lingzhong XU, Zhi HU, Anning MA, Zhaohui GONG, Tianqiang XU, Panshi WANG, Hua WANG, Chao HAO, Qingyu ZHOU, Mo HAO, Chengyue LI   +17 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Social Innovations in the Urban Context [PDF]

, 2016
This book addresses the practice of social innovation, which is currently very much in the public eye. New ideas and approaches are needed to tackle the severe and wicked problems with which contemporary societies are struggling. Especially in times of economic crisis, social innovation is regarded as one of the crucial elements needed to move forward.
Brandsen, Taco (Ed.), Cattacin, Sandro (Ed.), Evers, Adalbert (Ed.), Zimmer, Annette (Ed.)   +3 more
openaire   +4 more sources