Results 111 to 120 of about 3,898,666 (292)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Material Constraints for Assistant-Supported Learning

Social Interaction
This paper explores classroom desk interaction where the student has a visual impairment (VIS), and the interaction involves a third supportive party, the student’s learning support assistant.
Thomas L. W. Toft, Brian L. Due
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

On Unplanned Educational Activities in the Preschool

Social Interaction
This article concerns a learning environment in a preschool which includes a preschool teacher and two bilingual children. The article details how an activity of counting is introduced in the course of packing up a game and increasingly turns into an ...
Elisabeth Muth Andersen, Catherine E. Brouwer, Elisabeth Dalby Kristiansen, Maja Sigurd Pilesjö   +3 more
doaj   +1 more source

Social Interaction and Stock-Market Participation [PDF]

We investigate the idea that stock-market participation is influenced by social interaction. We build a simple model in which any given 'social' investor finds it more attractive to invest in the market when the participation rate among his peers is ...
Harrison Hong, Jeffrey D. Kubik, Jeremy C. Stein   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Collaborative and Cross-Modal Accomplishment of Practical Accord in a Video-Mediated Learning Situation

Social Interaction
Carrying out collaborative activities in video-mediated learning settings requires constant interactional work to maintain alignment between participants’ actions and the use of virtual and material artifacts (also known as ‘practical accord’).
tuire
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Accounting for Hybridized Activities in University Students’ Video-Mediated Breakout Room Interactions

Social Interaction
Using video recordings collected from an online language course, this study examines activities that university students engage in simultaneously while doing groupwork in breakout rooms on zoom.
Elina Helmiina Nuutinen
doaj   +1 more source

Examination of the effectiveness of a one-week camp on social interaction for youth with an Autism Spectrum Disorder [PDF]

, 2015
Background. Persons with autism spectrum disorder (ASD) each have unique abilities and limitations, but all experience challenges interacting with others.
O\u27Brien, Maureen Louise
core   +1 more source