Results 111 to 120 of about 8,448,369 (354)

Loneliness, social isolation, and chronic disease outcomes [PDF]

, 2020
J. A. Christiansen, Rikke Lund, Pamela Qualter, Christina Maar Andersen, Susanne S. Pedersen, Mathias Lasgaard   +5 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Social Isolation and Depression among Elderly from an Indian Urban Slum Population

Journal of the Indian Academy of Geriatrics
Background: The aim of the study was to understand the reported prevalence of subjective, objective social isolation, marginal family, and marginal friendship ties in relation to each other.
Mohan Kumar, Manisha Ruikar, V. L. Surya
doaj   +1 more source

Social Isolation Sport and Exercise Disruptions and Impacts on the Elderly as a Vulnerable Group

, 2022
Vadivelu Moodley
openalex   +1 more source

Practicing Social Isolation During a Pandemic in Brazil: A Description of Psychosocial Characteristics and Traits of Personality During COVID-19 Lockout [PDF]

, 2021
Daniela Sacramento Zanini, Evandro Morais Peixoto, Josemberg Moura de Andrade, Lucía Tramonte   +3 more
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Loneliness, social isolation and psychiatric disorders: insights from the National Mental Health Survey in Korea

BJPsych Open
Background Loneliness and social isolation pose significant public health concerns globally, with adverse effects on mental health and well-being. Although the terms are often used interchangeably, loneliness refers to the subjective feeling of lacking
Eun Jung Kim, Ji Hyun An, Jin Young Jung, Bong Jin Hahm, Jin Pyo Hong   +4 more
doaj   +1 more source

Long-term social isolation increases visceral pain in rats [PDF]

, 2022
Xuelong Zhou, Xiaolu Zhou, Chenjing Zhang   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The relationship between social isolation and cognitive function in older patients with chronic obstructive pulmonary disease: a latent profile analysis

BMC Geriatrics
Background To explore the potential classes of social isolation in older patients with chronic obstructive pulmonary disease (COPD), analyze the influencing factors of these classes, and investigate the relationship between different classes and ...
Minghua Han, Hongxia Wu, Huize Xu, Jian Zhao, Zhongwen Chang, Qian Zhao   +5 more
doaj   +1 more source