Results 111 to 120 of about 1,524,576 (347)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Loneliness, social isolation and psychiatric disorders: insights from the National Mental Health Survey in Korea

BJPsych Open
Background Loneliness and social isolation pose significant public health concerns globally, with adverse effects on mental health and well-being. Although the terms are often used interchangeably, loneliness refers to the subjective feeling of lacking
Eun Jung Kim, Ji Hyun An, Jin Young Jung, Bong Jin Hahm, Jin Pyo Hong   +4 more
doaj   +1 more source

PROLONGED SOCIAL ISOLATION IMPAIRS LEARNING IN THE ACTIVE AVOIDANCE CONDITIONING TASK IN FEMALE RATS

, 2023
Nataliya Krupina, Sophie D. Shirenova, Н. Н. Хлебникова   +2 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The relationship between social isolation and cognitive function in older patients with chronic obstructive pulmonary disease: a latent profile analysis

BMC Geriatrics
Background To explore the potential classes of social isolation in older patients with chronic obstructive pulmonary disease (COPD), analyze the influencing factors of these classes, and investigate the relationship between different classes and ...
Minghua Han, Hongxia Wu, Huize Xu, Jian Zhao, Zhongwen Chang, Qian Zhao   +5 more
doaj   +1 more source

Social Exclusion, Social Isolation and the Distribution of Income [PDF]

Social exclusion can be distinguished from social isolation, defining social isolation as the phenomenon of non-participation (of an individual or group) in a society's mainstream institutions, while reserving 'social exclusion' for the subset of cases ...
Brian Barry
core  

Eliminating Social Homelessness: Providing a Home to Grow [PDF]

, 2016
Middle school students who belong to marginalized identity groups often experience alienation and isolation. These feelings are compounded for multi-marginalized students who experience social homelessness–a term Harrison (2015) uses to describe students
Akos, Patrick, Duquette, Kevin, Harrison, Rydell   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The association between mental status, personality traits, and discrepancy in social isolation and perceived loneliness among community dwellers

BMC Public Health
Background Social isolation and loneliness can co-occur; however, they are distinct concepts. There is discrepancy as some people feel lonely in social isolation, while others do not.
Kumi Watanabe Miura, Takuya Sekiguchi, Mihoko Otake-Matsuura   +2 more
doaj   +1 more source