Results 121 to 130 of about 1,524,576 (347)

COMMUNITY-LEVEL SOCIAL CAPITAL AND SOCIAL ISOLATION IN JAPAN: A MULTILEVEL PANEL STUDY [PDF]

, 2017
Masashige Saito, Katsunori Kondo, Jun Aida, Naoki Kondo, Toshiyuki Ojima   +4 more
openalex   +1 more source

Targeted LGBT Senior Housing: A Study of the Needs and Perceptions of LGBT Seniors in Chicago [PDF]

, 2005
Although lesbian gay bisexual and transgendered (LGBT) seniors face issues similar to their heterosexual counterparts such as declining health, dwindling finances, depression, social isolation, and ageism, they also face unique issues such as ...
Curtis Jones, Grace Gedar
core  

Suicide ideation of individuals in online social networks

, 2013
Suicide explains the largest number of death tolls among Japanese adolescents in their twenties and thirties. Suicide is also a major cause of death for adolescents in many other countries.
Attila Szolnoki, BA Pescosolido, CR Shalizi, D Krackhardt, D Romer, DJ Watts, DL Trout, G Palla, Hiroko Onari, I Kawachi, Issei Kurahashi, J Brezo, JJ Mann, JN Rosenquist, JP Onnela, LF Berkman, M Wray, MS Gould, Naoki Masuda, P Hedström, PS Bearman, RA Stine, RD Baller, RD Baller, S Aral, S Cui, TE Joiner Jr, TJ VanderWeele   +27 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Psychopathology of social isolation

Journal of Exercise Rehabilitation, 2014
The most important defining factor of being human is the use of symbolic language. Language or communication problem occurs during the growth, the child will have a higher risk of social isolation and then the survival will be threatened constantly. Today, adolescents and youths are familiar with computer and smart-phone devices, and communication with
openaire   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Cognitive health risks posed by social isolation and loneliness in older Korean Americans [PDF]

, 2021
Yuri Jang, Eun Young Choi, Nan Sook Park, David A. Chiriboga, Lei Duan, Miyong T. Kim   +5 more
openalex   +1 more source

65+ Membership Scheme [PDF]

, 2015
This report shares the journey of three partners' experiment with digital technology to address societal challenges linked to ageing and social isolation.
Burley, Tim, Lane, Ollie, Windle, Amanda
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source