Results 31 to 40 of about 346,144 (257)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Association between internet use and social isolation among nursing home residents: a chain mediation model

BMC Geriatrics
Background Social isolation poses a significant threat to the health of older adults. However, there has been a lack of attention to the relationship between Internet use and social isolation.
Qiyuan Huang, Huangqin Liu, Wan Cheng, Sheng Wu, Song Ge, Yuanfeng Lu, Jinyi Wu, Bingqian Ou, Huimin Xiao   +8 more
doaj   +1 more source

Rate of Social Isolation by Geographic Location Among Older Adults: AAA LongROAD Study

Frontiers in Public Health, 2021
Introduction: Social isolation is a modifiable risk factor for negative health outcomes among older adults. This work assessed the relationship between geography (i.e., urban vs.
Laura Lynch, Thelma J. Mielenz, Guohua Li, Guohua Li, David W. Eby, Lisa J. Molnar, Marian E. Betz, Carolyn DiGuiseppi, Linda L. Hill, Vanya Jones, David Strogatz   +10 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The associations of social isolation with depression and anxiety among adults aged 65 years and older in Ningbo, China

Scientific Reports
Social isolation was associated with emotional problems (depression and anxiety) among older adults, however, little is known in China. Thus, we conducted a cross-sectional study including 6,664 ≥ 65 years older adults in Ningbo, China. We collected data
Lian Li, Kaijie Pan, Jincheng Li, Meiqin Jiang, Yan Gao, Hongying Yang, Guolin Bian   +6 more
doaj   +1 more source

Social isolation induces hyperactivity and exploration in aged female mice.

PLoS ONE, 2021
Prolonged social isolation is associated with poor physical and mental health outcomes, findings observed in both humans, and rodent models of isolation.
D Gregory Sullens, Kayla Gilley, Kendall Jensen, Elisabeth Vichaya, Sara L Dolan, Melanie J Sekeres   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Modulation of social valence by insular cortex activity during acute social isolation in mice

Molecular Brain
For social animals, social isolation is a potential threat to survival, and therefore can be considered innately aversive. Long-term social isolation induces a variety of social and affective deficits and has been used as a stress model in animal studies,
Kanae Hiyoshi, Daichi Matsushita, Ayako M. Watabe   +2 more
doaj   +1 more source

Advancing loneliness and social isolation as global health challenges: taking three priority actions

Public Health Research & Practice, 2023
Loneliness and social isolation have been identified as critical global health issues in the aftermath of the coronavirus disease 2019 (COVID-19) crisis.
Michelle H Lim , Pamela Qualter, Ding Ding, Julianne Holt-Lunstad, Christopher Mikton, Ben J Smith   +5 more
doaj   +1 more source