Results 41 to 50 of about 1,514,946 (349)

Influence of pre-reproductive maternal enrichment on coping response to stress and expression of c-Fos and glucocorticoid receptors in adolescent offspring [PDF]

, 2017
Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function.
Begega, Azucena, Berretta, Erica, Caporali, Paola, Cutuli, Debora, DE BARTOLO, Paola, Foti, FRANCESCA IRENE, Gelfo, Francesca, Laricchiuta, Daniela, Pasqualini, Greta, Pesoli, Matteo, Petrosini, Laura, Sampedro Piquero, Patricia   +11 more
core   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Association between internet use and social isolation among nursing home residents: a chain mediation model

BMC Geriatrics
Background Social isolation poses a significant threat to the health of older adults. However, there has been a lack of attention to the relationship between Internet use and social isolation.
Qiyuan Huang, Huangqin Liu, Wan Cheng, Sheng Wu, Song Ge, Yuanfeng Lu, Jinyi Wu, Bingqian Ou, Huimin Xiao   +8 more
doaj   +1 more source

Social isolation induces hyperactivity and exploration in aged female mice.

PLoS ONE, 2021
Prolonged social isolation is associated with poor physical and mental health outcomes, findings observed in both humans, and rodent models of isolation.
D Gregory Sullens, Kayla Gilley, Kendall Jensen, Elisabeth Vichaya, Sara L Dolan, Melanie J Sekeres   +5 more
doaj   +1 more source

Out of the Frying Pan, Into the Fire: Mixed Affective Reactions to Social Proximity in Borderline and Avoidant Personality Disorders in Daily Life

, 2014
Social proximity typically helps individuals meet their belongingness needs, but several forms of psychopathology, including borderline and avoidant personality disorders (BPD and APD, respectively) are characterized by social difficulties.
Berenson, Kathy R., Downey, Geraldine, Gadassi, Reuma, Rafaeli, Eshkol, Snir, Avigal   +4 more
core   +1 more source

Defining a relevant architecture in South Africa [PDF]

, 2000
Architecture in South Africa is at a crossroads. Afteryears of repression and isolation during which contemporary architecture lost its way, there is now a desperate need for architects to respond to the social a nd cultural challenges of a society riven
Biermann, Buchanan, Chipkin, Competition, Cooke, Forjaz, Hallen, Harber, Harber, Harber, Herwitz, Japha, Lipman, Marschall, Marschall, Noero, Nutall, Papini, Paul Sanders, Radebe, Sachs, Seneque, Van Zyl   +22 more
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

The reproduction trajectories of institutions in relation to social isolation of individual population groups in regions of Russia [PDF]

, 2015
This article deals with spatial socio-demographic isolation as a factor of the existing settlement system in Russian regions. Theoretically, the phenomena of solitude and social isolation have their own demographic, socio-economic, and psychological ...
Berzin, B. Yu., Kuzmin, A. I., Pyshmintseva, O. A.   +2 more
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source