Results 51 to 60 of about 346,144 (257)

Perceived Social Isolation and Outcomes in Patients With Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPerceived social isolation has been shown to have a negative impact on health outcomes, particularly among older adults. However, these relationships have not been fully examined among patients with heart failure.
Sheila M. Manemann, Alanna M. Chamberlain, Véronique L. Roger, Joan M. Griffin, Cynthia M. Boyd, Thomas K. M. Cudjoe, Daniel Jensen, Susan A. Weston, Matteo Fabbri, Ruoxiang Jiang, Lila J. Finney Rutten   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Post-weaning social isolation alters sociability in a sex-specific manner

Frontiers in Behavioral Neuroscience
Adolescence is a critical period for brain development in humans and stress exposure during this time can have lasting effects on behavior and brain development.
Teneisha Myers, Elizabeth A. Birmingham, Brigham T. Rhoads, Anna G. McGrath, Nylah A. Miles, Carmen B. Schuldt, Lisa A. Briand, Lisa A. Briand   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Neighborhood social cohesion and physical disorder in relation to social isolation in older adults: racial and ethnic differences

BMC Public Health
Background Neighborhood factors of social isolation have been understudied, hindering efforts to reduce social isolation at the neighborhood level. This study aims to investigate the longitudinal effects of neighborhood social cohesion and physical ...
Weidi Qin, Emily J. Nicklett, Jiao Yu, Ann W. Nguyen   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Association Between Ego-Resilience and Social Isolation Among Urban Older People

Gerontology and Geriatric Medicine
Social isolation among older adults affects their physical and mental health. Ego-resilience is associated with flexible adaptation to various environments and acceptable behaviors.
Kazuaki Hashimoto MD, PhD, Takeaki Takeuchi MD, PhD, Kazushige Ihara MD, PhD, Shuichi Obuchi PT, PhD, Hisashi Kawai PhD, Hirohiko Hirano DDS, PhD, Yoshinori Fujiwara MD, PhD, Kim Hunkyung PhD, Yutaka Watanabe DDS, PhD, Masahiro Hashizume MD, PhD   +9 more
doaj   +1 more source

GAMBARAN KEMAMPUAN INTERAKSI SOSIAL PASIEN ISOLASI SOSIAL SETELAH PEMBERIAN SOCIAL SKILLS THERAPY DI RUMAH SAKIT JIWA

Jurnal Ilmiah Kesehatan, 2018
Social isolation is one of the nursing diagnoses that can be established in patients who are symptomatic to withdraw, withdraw from social activities and do not want to interact with others even with nurses.
Sukma Ayu Candra Kirana
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

URDU-INCREASING TRENDS OF SUICIDE AND ITS PREVENTION IN THE LIGHT OF ISLAMIC TEACHINGS

دی اسکالر
Islam believes that human life is a divine trust of Allah and it is a fundamental religious responsibility to protect it. Modern times have seen increasing suicide tendencies due to economic needs, loneliness, destruction of families, mental illnesses ...
Abdul Salam Tunio, Bashir Ahmed Rind
doaj