Results 131 to 140 of about 1,015,661 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An Explorative Social Life Cycle Assessment for Wild Harvest and Cultivation of F. lumbricalis in the Baltic Sea Region

Environmental and Climate Technologies
This study applies a Social Life Cycle Assessment (S-LCA) to evaluate the social impacts of Furcellaria lumbricalis red macroalgae production through wild harvesting (WH) and offshore cultivation (OC) in the Baltic Sea Region. As macroalgae gain interest
Paoli Riccardo, Pechsiri Joseph Santhi, Souza Alexandre, Romagnoli Francesco   +3 more
doaj   +1 more source

Beyond the fields: Unravelling the social consequences of green pea protein production from a Swedish perspective

Cleaner and Responsible Consumption
Despite legume-based proteins being more environmentally sustainable compared to conventional meat proteins, these products need to be backed up by socially sustainable supply chains, as upstream and downstream social impacts may hinder their overall ...
Edoardo Desiderio, Karin Östergren
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Personal Saving and Social Security in Italy: Fresh Evidence from a Time Series Analysis [PDF]

The paper provides an econometric analysis of the aggregate saving function of Italian households in the vein of the life cycle theory. Results from an ECM representation based on yearly data for 1951-1998 point to depressive effects on private ...
Francesco Zollino
core  

Simulation aided life cycle sustainability assessment framework for manufacturing design and management [PDF]

, 2016
Decision making for sustainable manufacturing design and management requires critical considerations due to the complexity and partly conflicting issues of economic, social and environmental factors.
Gbededo, Mijoh Ayodele, Liyanage, Kapila, Oraifige, Ilias   +2 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Intersectionality Between Amazon and Commodities Production: A Close Look at Sustainability

Land
Food production’s environmental, economic, and social challenges should be demystified through quantitative data. Therefore, the objective of this paper was to investigate the ecoregional sustainability of the Amazon biome from the perspective of the ...
Adriane Terezinha Schneider, Rosangela Rodrigues Dias, Mariany Costa Deprá, Darissa Alves Dutra, Richard Luan Silva Machado, Cristiano Ragagnin de Menezes, Leila Queiroz Zepka, Eduardo Jacob-Lopes   +7 more
doaj   +1 more source

Quantifying and assessing impacts of building processes in a triple bottom line approach [PDF]

, 2011
The paper is based on a research project undertaken by the University of Technology, Sydney in examining the integration of economic, social and environmental considerations throughout the building process of a development.
Ding, GK, Liu, J, Samali, B
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source