Results 121 to 130 of about 137,270 (302)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Life cycle assessment of integrated food chains : A Swedish case study of two chicken meals

, 2008
Background, aims, and scope: Food is a vital human need that not only provides essential nutrition but is also a key part of our social life as well as being a valued sensory experience. However, food, or rather the production chain of food, from primary
Sonesson, Ulf,, Davis, Jenny,
core   +1 more source

Life cycle sustainability assessment: An ongoing journey

, 2020
As the call for sustainable solutions at operational, industrial, and policy level increases, the need for a comprehensive assessment tool has been addressed by literature and practitioners.
Zanni, Sara, Sara Zanni, Awere, Eric, Eric Awere, Bonoli, Alessandra, Alessandra Bonoli   +5 more
core   +1 more source

Monetizing Social Life Cycle Assessment (SLCA): A Case Study in SMEs Tapioca Industry in Lampung, Indonesia

Applied Environmental Research
To verify the responsible and sustainable functioning of circular economy (CE), assessing the sustainability of CE methods is essential. The consistent absence of a social aspect within the CE has been a recurring topic in research.
yosep, Unang Mulkhan, Udin Hasanudin, Dewi Agustina Iryani   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Sustainability of Food Products Applying Integrated Life Cycle Tools [PDF]

The agri-food industry is a significant resource for the European economy. However, the competitiveness of this industry seems to be at risk due to its many structural problems (i.e.
Barbara Burchi, Angela Tarabella
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The use of Pugh Matrix for the indentification of social issues within Social Organisational Life Cycle Assessment (SO-LCA): a methodological outline.

, 2020
this study proposes a methodological outline for the definition of a set of relevant social issues for a specific sector. The aim is to address the assessment from an organisational perspective and for this reason, the methodological outline is developed
Matthias Finkbeiner, Luigia Petti, Manuela D'Eusanio   +2 more
core  

Socioeconomic indicators as a complement to life cycle assessment : An application to salmon production systems

, 2009
Background, aim, and scope: There is a growing recognition on the part of industry, policymakers, and consumers that sustainable industry practices are needed to maintain environmental and social well being.
Kasperczyk, N., Scholz, A.J., Kruse, S.A., Flysjö, Anna,   +3 more
core   +1 more source

Evaluating the social performance of Ecuadorian textile MSMEs using Social Organizational Life Cycle Assessment

Cleaner Environmental Systems
Integrating sustainability into Micro, Small, and Medium-sized Enterprises (MSMEs) poses challenges due to limited resources, low social awareness, and particular cultural factors.
Erik Sigcha, Dolores Sucozhañay, Lorena Siguenza-Guzman, Paul Vanegas   +3 more
doaj   +1 more source