Results 141 to 150 of about 137,270 (302)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Linear programming as a tool in life cycle assessment
, 2020 Linear Programming (LP) is a powerful mathematical technique that can be used as a tool in Life Cycle Assessment (LCA). In the Inventory and Impact Assessment phases, in addition to calculating the environmental impacts and burdens, it can be used for ...
Azapagic, A, Clift, R
core
Simulation aided life cycle sustainability assessment framework for manufacturing design and management [PDF]
, 2016 Decision making for sustainable manufacturing design\ud and management requires critical considerations due to the\ud complexity and partly conflicting issues of economic, social and\ud environmental factors. Although there are tools capable of assessing\
Oraifige, Ilias +4 more
core
Multi-Criteria LCA Framework for Sustainable Hydropower Refurbishment Design
EnergiesHydropower refurbishment is increasingly recognized as a key strategy for maintaining renewable electricity generation and minimizing the environmental and social impacts of developing new infrastructure.
Elena Simina Lakatos +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Towards social life cycle assessment of food delivery. Findings from the Italian case study [PDF]
Purpose: The growth of global food delivery (FD), which could reach a market value of 1510 billion dollars by 2027, could raise significant sustainability concerns, especially in terms of the social impact related to the expansion of the gig economy ...
Mary Gio Zaki +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Materials Today SustainabilityThis study evaluates the mechanical performance and life cycle sustainability of post-consumer recycled polylactic acid (rPLA) for use in the fused filament fabrication of 3D-printed gear components.
Mohammad Raquibul Hasan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source