Results 141 to 150 of about 1,015,661 (306)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Multi-Criteria LCA Framework for Sustainable Hydropower Refurbishment Design

Energies
Hydropower refurbishment is increasingly recognized as a key strategy for maintaining renewable electricity generation and minimizing the environmental and social impacts of developing new infrastructure.
Elena Simina Lakatos, Sára Ferenci, Roxana Maria Albu (Druta), Marius-Viorel Posa, Radu Adrian Munteanu, Loránd Szabó, Lucian-Ionel Cioca   +6 more
doaj   +1 more source

Stakeholder Analysis and S-LCA for the agri-food sector: are there elements of overlapping and complementarities? [PDF]

, 2014
INTRO, BACKGROUND AND AIMS. In recent years, increasing attention is paid to political actions and public interventions that are established as a result of a share owned by citizens of a nation, by the local population.
Bendetto G., Corinto G. L.
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

PDSA-kehän käytettävyys ikääntyneiden Intoa elämään -ryhmätoiminnassa Espoossa [PDF]

, 2012
Opinnäytetyömme tarkoituksena oli selvittää PDSA-kehän käyttöä Espoossa järjestetyssä Intoa elämään -ryhmätoiminnassa. Tarkastelimme erityisesti sitä, kuinka PDSA-kehän tapaisella jatkuvalla laadunparantamismallilla voidaan tukea ikääntyneiden ...
Niittymäki, Paula, Torkkeli, Jasmin
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Fruits and vegetables supply chains specificities and stakes as element of discussion on Social-LCA [PDF]

, 2010
International audienceAgri-food supply chains are at the heart of sustainable development concerns. In order to comprehend whole complex parameters and their global impacts, it appeared necessary to adopt a systemic approach, justifying a Life Cycle ...
Feschet, P., Garrabé, M., Loeillet, D., Macombe, C.   +3 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Advancing circular additive manufacturing: Life cycle sustainability assessment of gears made from recycled polylactic acid

Materials Today Sustainability
This study evaluates the mechanical performance and life cycle sustainability of post-consumer recycled polylactic acid (rPLA) for use in the fused filament fabrication of 3D-printed gear components.
Mohammad Raquibul Hasan, Ian J. Davies, Alokesh Pramanik, Michele John, Wahidul K. Biswas   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source