Results 91 to 100 of about 680,700 (262)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Endless scrolling through social media and work boredom: a dynamic spillover of information overload

Organization Management Journal
Based on the premise that young adults, as knowledge workers, are overstimulated by a constant bombardment of information from digital channels like social media, this paper aims to explore how the information overload, largely redundant and noisy ...
Tathagata Bhowmik
semanticscholar   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

The relationship between college students’ social media use and core self-evaluation: the chain mediating effect of information overload and fear of missing out

BMC Psychiatry
Background Social media has become an integral part of college students’ daily lives, yet the issues of information overload and emotional distress it brings are increasingly prominent.
Linlin Wang, Leyun He, Wanyu Huang, Tingting Wang, Qinchen Jiang, Zhi Li, Qiyue Mao, Shengnan Ruan, Ming Yang, Cui Wang, Fan Wang, Minghao Pan   +11 more
doaj   +1 more source

Consumers’ Nostalgic Re-Engagement with Media in Emerging Markets: Emotional Needs, Content Overload, and Exposure

Organizations and Markets in Emerging Economies
Grounded in uses-and-gratifications (U&G) theory, this research examines how millennials (Gen Y) nostalgically re-engage with media content and its outcomes in the emerging market context of India.
Rohit Yadav, Linda Hollebeek, Algis Gaižutis, Mohit Yadav   +3 more
doaj   +1 more source

Exploring The Impact of Social Media Utilization on Perceived Information Overload: The Mediating Role of Information Disorder Experiences

Journal of Information & Knowledge Management
Social media platforms provide numerous benefits, such as global connectivity and rapid information sharing, but they also pose significant challenges, including managing interactions and assessing content reliability.
M. N. Masrek, Mohammad Fazli Baharuddin, Heriyanto Heriyanto   +2 more
semanticscholar   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Social Media Use: Association with Digital Stress and Anxiety and Depression Symptoms in Youth

Psychological Topics
The aim of the present study was to examine the relationship between social media use and digital stress (availability stress, approval anxiety, fear of missing out, connection overload and online vigilance), and whether social media use and digital ...
Tamara Martinac Dorčić, Sanja Smojver-Ažić, Sanja Bradić   +2 more
doaj   +2 more sources

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source