Results 101 to 110 of about 680,700 (262)

Deciphering the underlying repercussions of cognitive overload on university students' fatigue, frustration and academic productivity: Implementation of stimulus–organism–response model

Acta Psychologica
Extant studies suggest that cognitive overload, as a nascent phenomenon, has become increasingly pervasive among university students, precipitating a multitude of detrimental consequences.
Hua Pang, Xiaoyi Jin, Wanting Zhang
doaj   +1 more source

The Mechanisms of Social Media-Induced Anxiety: An S-O-R Perspective on FoMO, Social Comparison, Information Overload, and Meritocracy among University Students

Media and Communication Research
: Amid growing concerns over the psychological impacts of social media on Chinese university students, this study employs the Stimulus-Organism-Response (S-O-R) framework to investigate how Fear of Missing Out (FoMO), Social Comparison, information ...
Lu Li
semanticscholar   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Drowning in a Sea of News: The Role of Doomscrolling, News Overload, and News Failure in the Relationship Between News Search on Social Media and News Avoidance in Natural Disaster Situations

Communication Studies
Türkiye is a region prone to earthquakes, and its fault structures generate destructive earthquakes on a regular basis. In this sense, a second devastating earthquake occurred in February 2023, and a great deal of information and news about it was ...
Mihrali Koselioren, Cihan Cakir
semanticscholar   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

The effects of negative social media connotations on subjective wellbeing of an ageing population: A stressor-strain-outcome perspective.

PLoS ONE
In recent years, users' privacy concerns and reluctance to use have posed a challenge for the social media and wellbeing of its users. There is a paucity of research on elderly users' negative connotations of social media and the way these connotations ...
Izzal Asnira Zolkepli, Rehan Tariq, Pradeep Isawasan, Lalitha Shamugam, Hasrina Mustafa   +4 more
doaj   +1 more source

Managing Information Overload in a Pandemic: Influence of Social Media on Vaccine Attitudes in the Digital Age

International Journal of Health Sciences
Purpose: This study examined how social media influences public health decisions, focusing on how information overload during a pandemic impacts vaccine hesitancy and acceptance across demographics.
Y. Adekunle, A. Ogwezzy-Ndisika, Ismail A. Ibraheem   +2 more
semanticscholar   +1 more source