Results 91 to 100 of about 1,316,463 (304)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Dog owners’ awareness of the zoonotic potential of endoparasites of their pets and potential risk factors for humans

open access: yesFrontiers in Animal Science
AimThe aim of this research was to establish the attitudes of dog owners in Serbia towards caring for their dogs with particular emphasis on veterinary care and parasite control.MethodsThe study presents a social-medical approach to the problem of ...
Marko Ristić   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Pensamento clássico da saúde pública paulista na era dos centros de saúde e educação sanitária

open access: yesRevista de Saúde Pública
Revisão histórica sobre ideias e conceitos da organização sanitária que se seguiram à introdução do modelo do Centro de Saúde distrital pela reforma do Serviço Sanitário em 1925.
Guilherme Arantes Mello
doaj  

Determination of the Need and Assessment Algorithms of the Scope of Activity of Regional Centers for Diagnosis and Treatment of Bronchopulmonary Dysplasia

open access: yesGalician Medical Journal, 2016
Graphical and polynomial (quantitative) regional model of bronchopulmonary dysplasia (BPD) prevalence, depending on the number of premature children, was substantiated, composed and proposed for use for the first time.
A. F. Shypko
doaj  

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