Results 51 to 60 of about 159,474 (304)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Online social capital : mood, topical and psycholinguistic analysis [PDF]
, 2013 Social media provides rich sources of personal information and community interaction which can be linked to aspect of mental health. In this paper we investigate manifest properties of textual messages, including latent topics, psycholinguistic features,
Berk, Michael +4 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Synesius, bishop of Ptolemais: Outline of the life and work [PDF]
Религия, церковь, общество, 2013 Synesius, bishop of Ptolemais, played an important role in the intellectual life of the Roman Empire on the turn of IV–V centuries. The article is devoted to the life and activity of Synesius in the context of his literary works that reflected the main ...
Olga Vladimirovna Przhigodzkaja
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Genres as Social Affect: Cultivating Moods and Emotions through Playlists on Spotify
Social Media + Society, 2019 This article bridges work on media technologies and affect theories through an analysis of how users appropriate playlists on Spotify. Our study draws on 30 interviews with users of music streaming services in Costa Rica and an analysis of their accounts
Ignacio Siles +3 more
doaj +1 more source
Life Domain Research Report Series: Youth and Parent Health and Well Being (2010 UPDATE) [PDF]
, 2009 Children and youth who have participated in children’s mental health services often continue to live with a variety of emotional and behavioural challenges after service involvement has ended (Cameron, de Boer, Frensch, & Adams, 2003).
Cameron, Gary +3 more
core +1 more source
Mood and positive testing in social interaction [PDF]
European Journal of Social Psychology, 2011 Why, how and when does mood influence positive testing, that is, the selection of matching questions, when people actively search for information about others they meet? In four experiments, we demonstrated that happy mood increased positive testing compared to sad mood.
Dardenne, Benoît +3 more
openaire +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source