Results 71 to 80 of about 479,984 (317)

How to network in online social networks [PDF]

2014 IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS), 2014
In this paper, we consider how to maximize users' influence in Online Social Networks (OSNs) by exploiting social relationships only. Our first contribution is to extend to OSNs the model of Kempe et al. [1] on the propagation of information in a social network and to show that a greedy algorithm is a good approximation of the optimal algorithm that is
Neglia, Giovanni, Ye, Xiuhui, Gabielkov, Maksym, Legout, Arnaud   +3 more
openaire   +4 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Quantification in social networks

2015 IEEE International Conference on Data Science and Advanced Analytics (DSAA), 2015
In many real-world applications there is a need to monitor the distribution of a population across different classes, and to track changes in this distribution over time. As an example, an important task is to monitor the percentage of unemployed adults in a given region.
Milli L, Monreale A, Rossetti G, Pedreschi D, Giannotti F, Sebastiani F   +5 more
openaire   +4 more sources

The pneumococcal social network

PLOS Pathogens, 2020
Gram-positive bacteria employ an array of secreted peptides to control population-level behaviors in response to environmental cues. We review mechanistic and functional features of secreted peptides produced by the human pathogen Streptococcus pneumoniae.
Surya D. Aggarwal, Hasan Yesilkaya, Suzanne Dawid, N. Luisa Hiller   +3 more
openaire   +4 more sources

In Search of the Healthy Immigrant Effect in Four West European Countries

Social Inclusion, 2019
The present research examines whether the ‘healthy immigrant effect’ thesis observed in the American context prevails also in the West European context. According to this thesis, immigrants are likely to be healthier than comparable nativeborn.
Dina Maskileyson, Moshe Semyonov, Eldad Davidov   +2 more
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Social Network Analysis [PDF]

, 2006
In knowledge management (KM), one perspective is that knowledge resides in individuals who interact in groups. Concepts as communities-of-practice, knowledge networks, and “encultured knowledge” as the outcome of shared sense-making (Blackler, 1995) are built upon this perspective.
Dekker, D.J., Hendriks, P.H.J.
openaire   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source