Results 91 to 100 of about 309,564 (337)
Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues
Advanced Materials, EarlyView.A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad +6 more
wiley +1 more source
Advanced Materials, EarlyView.A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen +16 more
wiley +1 more source
Exploring Searle's Social Ontology [PDF]
, 1927 In this short article, I will explore John Searle’s social ontology project from the perspective of social epistemology. The outcome of my analysis is that language is decisive for the collective acquisition and production of knowledge.
Manee, Samal H. R.
core +1 more source
Ontology Merging as Social Choice [PDF]
, 2014 The problem of merging several ontologies has important applications in the Semantic Web, medical ontology engineering and other domains where information from several distinct sources needs to be integrated in a coherent manner.We propose
Endriss, Ulle, Porello, Daniele
core
Advanced Materials, EarlyView.A bioinspired nanozyme—triphenylphosphonium (TPP)‐dendritic mesoporous silica nanoparticle (DMSN)‐Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical‐sized bone defects rat ...
Yuwen Wang +16 more
wiley +1 more source
PERFORMATIVITY, SOCIAL ONTOLOGY, AND THE USES OF NARRATIVES IN LATIN AMERICA [PDF]
, 2015 : This article explains the relationship between performativity and social ontology in the case of Latin American narratives of resistance and liberation.
MARQUEZ, Ivan
core +2 more sources
Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming
Advanced Materials, EarlyView.Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung +6 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner +10 more
wiley +1 more source
Two approaches to naturalistic social ontology [PDF]
, 2023 Matti Sarkia, Tuukka Kaidesoja
openalex +1 more source
Ontology Building of Manufacturing Quality Knowledge for Design Decision Support [PDF]
, 2010 This work was funded by National Natural Science Foundation of China (No: 70472066, 70771091), the project of Bureau of Science, Technology and Industry for National Defence, China (No. Z142008A001), the NPU Foundation for Humanities, Social Science, and
EYNARD, Benoit +4 more
core +3 more sources