Results 81 to 90 of about 7,916,499 (329)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Ontology of laughter: social-ethical aspects [PDF]
, 2018 Laughter is very important emotional manifestation for human being. The understanding of laughter’s nature and the determination of its main characters can’t be ignored because laughter is the ability that characterizes and determines the very human way ...
Stebelska, Olexandra
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
“Is logic a physical variable?” Introduction to the Special Issue
Zagadnienia Filozoficzne w Nauce, 2020 “Is logic a physical variable?” This thought-provoking question was put forward by Michael Heller during the public lecture “Category Theory and Mathematical Structures of the Universe” delivered on 30th March 2017 at the National Quantum Information ...
Michał Eckstein, Bartłomiej Skowron
doaj
Social Ontology Documentation for Knowledge Externalization [PDF]
, 2010 Knowledge externalization and organization is a major challenge that companies must face. Also, they have to ask whether is possible to enhance its management.
Aranda Corral, Gonzalo A. +2 more
core +1 more source
Philosophy & Technology, 2016 In this paper, we engage in a philosophical investigation of how blockchain technologies such as cryptocurrencies can mediate our social world. Emerging blockchain-based decentralised applications have the potential to transform our financial system, our
Wessel Reijers, Mark Coeckelbergh
semanticscholar +1 more source
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Social Ontology and Immanent Realism
Phenomenology and Mind, 2016 What are the intentional objects of groups’ beliefs? This paper claims that they are immanent facts, i.e., facts which exist only within groups’ minds. Since in relevant literature the notion of immanent object and the related theory of “immanent realism”
Alessandro Salice
doaj +1 more source
Semantic Network Analysis of Ontologies [PDF]
, 2011 A key argument for modeling knowledge in ontologies is the easy re-use and re-engineering of the knowledge. However, current ontology engineering tools provide only basic functionalities for analyzing ontologies.
Hoser, Bettina +4 more
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source