Results 101 to 110 of about 1,876,704 (311)

Challenges of migration for the social pedagogy in Swedish context

open access: yes, 2016
The key aspects to how the Swedish social insurance system is implemented are a high degree of universalism and the promotion of equality. The aim of this article is to explore certain issues of complexity in recent societal changes, in order to ...
Dychawy Rosner, Irena
core  

SOCIALIZATION AS A THREAT: INVERSION IN THE MECHANISM OF SOCIAL CHANGE AND DISORGANIZATION

open access: yesВестник Северо-Кавказского федерального университета, 2022
The process of socialization, traditionally perceived as a mechanism for developing and reproducing of the social order, is viewed as a mechanism for social change and disruption.
Dmitry A. Lushnikov
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Social work discourses and the social work interview

open access: yes, 1989
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.It will be argued that, in order to understand particular exchanges between social workers and clients, it is essential to go beyond the view that sees them
Stenson, Kevin
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Social work and social development : a partnership in social change

open access: yes, 1997
Poverty, both relative and absolute is increasing worldwide. War, natural disasters and environmental degradation have exacerbated economic deprivation, social exclusion and political marginalisation for many of the earth's people.
Dominelli, Lena
core  

SOCIOCULTURAL AND GENDER ASPECTS OF PHENOMENON OF IMAGINATION IN HUMAN RIGHTS PHILOSOPHY

open access: yesОсвітній дискурс
Relevance of the research. In today's world, where gender equality is becoming an ethical and legal imperative, legal philosophy needs to integrate the phenomenon of imagination as a tool for legitimizing the social contract and deconstructing ...
Irina Yershova-Babenko
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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