Results 91 to 100 of about 1,876,704 (311)

Social enterprise networks and social capital: A case study in Scotland/UK [PDF]

open access: yes, 2014
The chapter focuses on how social aims and cooperative attitudes have been supported in the shaping of networks in Scotland, and why this is relevant for the sustainable development of social enterprise and communities. From this background, our main aim
Campbell, Colin, Sacchetti, Silvia
core  

A justiça de menores portuguesa na viragem do século xxi: uma expressão da cultura do controlo?

open access: yese-cadernos ces, 2013
The article relies on the culture of control theoretical assumptions to analyse the impact of neoliberal social policies on Portuguese youth justice. At the turn of the 21st century, Portuguese youth justice was subjected to significant structural and ...
Joana Maduro
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Social Media Activism

open access: yes
This book focuses on the referendums against water privatization in Italy and explores how activists took to social media, ultimately convincing twenty-seven million citizens to vote.
Cernison, Matteo
core   +1 more source

The role of urban greenery in the sustainable development of the city Bydgoszcz

open access: yesJournal of Education, Health and Sport, 2016
The problem of the development concerns green areas of the city of Bydgoszcz. It determines the extent to which the urban greenery and its functioning in the city pursue the principles of sustainable development.
Magdalena Oleś, Kazimierz Harłoziński
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Revitalising radical social work

open access: yes, 2017
The call to radicalise social work is not new. Some of us are “mature” enough to remember Bailey and Brake’s 1975 treatise on the subject. Radical concepts slip and slide around the social work agenda in a semi-sustainable way.
Briskman, Linda (R18870)
core  

The Eye of the Beholder: Violence as a Social Process

open access: yesInternational Journal of Conflict and Violence, 2011
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 10.0px Verdana;">&nbsp;</p><p class="MsoNormal"><p class="MsoNormal">A triangular reconstruction of the social dynamics of violence offers a means to bridge the gap between ...
Teresa Koloma Beck
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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