Results 91 to 100 of about 1,068,475 (313)
Social policy reform and participation in Latin America: the Bolivian experiment
, 1998 Using the example of reforms in Bolivia, the author discusses `second generation' structural and institutional reforms taking place in Latin America, in the aftermath of Structural Adjustment Programmes' (SAPs) failure to reduce poverty and inequality ...
Ticehurst, Simon
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nordic Social Work ResearchThis pilot and feasibility study includes seven child welfare services (CWS) that completed a total of 136 surveys. The research design, initially developed and conducted in Sweden, is aimed at increasing knowledge about violence against children within ...
Rakel Aasheim Greve +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mothers’ Perception of Social Participation and Its Reflection on their Children
, 2023 This qualitative research aims to examine mothers' perception of social participation and their practices to improve their children's social participation skills.
Tarhan, Ö.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Is there a crisis of political participation? [PDF]
, 2003 The value of this article is in analysing primary data to show that, while rising education levels do not spur differential rates of electoral participation, they do trigger differential rates of non-electoral participation.
Seyd, Ben, Curtice, John
core
Life course social connectedness : age-cohort trends in social participation
, 2019 Social connectedness has emerged in recent decades as a key determinant of well-being. Considering its importance, several studies have sought to describe how overall trends in society have changed over the years, while others have been more concerned ...
Ang, Shannon
core +1 more source