Results 71 to 80 of about 13,578,919 (257)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Leisure and social participation for the elderly. Assessment of a sociocultural and community development program in Granollers [PDF]

, 2012
This article analyzes an assessment investigation about a leisure and social participation (“Implica-Acción”) program for elderly people in Granollers.
Morata García, Txus, Palasí Luna, Eva
core  

Participation in Social Media: Studying Explicit and Implicit Forms of Participation in Communicative Social Networks [PDF]

, 2016
The diverse forms of participation in social media raise many methodological and ethical issues that should be acknowledged in research. In this paper, participation in social media is studied by utilising the framework of explicit and implicit ...
Janne Matikainen, Matikainen, Janne, Mikko Villi, Villi, Mikko   +3 more
core   +1 more source

The Effects of the MONOZUKURI Program on Executive Function Among Community‐Dwelling Older Adults: A Randomized Controlled Trial

Brain and Behavior
Introduction This study aimed to examine the effect of the MONOZUKURI program, a cognitive intervention related to creative activities (handicrafts and creative cooking), on cognitive function in community‐dwelling older adults.
Ai Iizuka, Susumu Ogawa, Daisuke Cho, Kyoko Fujihira, Yan Li, Kenichiro Sato, Keigo Hinakura, Kimi Estela Kobayashi‐Cuya, Hiroyuki Suzuki   +8 more
doaj   +1 more source

Impact of the COVID-19 Pandemic on New Long-term Care Insurance Applications and All-cause Mortality in Older Adults in a Japanese Metropolitan Cohort: An Interrupted Time-series Analysis

Journal of Epidemiology
Background: New long-term care insurance (LTCI) certifications and mortality are key outcomes in cohort studies involving older adults; however, the coronavirus disease 2019 (COVID-19)’s comprehensive impacts on these outcomes remain underexplored.
Satoshi Seino, Toshiki Hata, Hiroki Mori, Shoji Shinkai, Yoshinori Fujiwara, Erika Kobayashi   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Participation in social development and integration in Sub-Saharan Africa

, 1986
Discusses participation in social development and integration in Sub-Saharan Africa in terms of economic and social ...
Agere, Sam
core   +1 more source

Tactile sensation moderates the association between hand dexterity and higher-level cognition in older adults with and without MCI

Frontiers in Aging Neuroscience
BackgroundTactile sensation and hand dexterity decline with age and are associated with later-life cognition, yet it remains unclear whether tactile sensation moderates the strength of hand motor–cognitive associations.
Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Susumu Ogawa, Hiroko Matsunaga, Keigo Hinakura, Shun Yoshikoshi, Shun Yoshikoshi, Yan Li, Maki Nishinakagawa, Hiroyuki Suzuki   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Impact of the First–Fourth Waves of the COVID-19 Pandemic on New Applications for Long-term Care Insurance in a Metropolitan Area of Japan

Journal of Epidemiology, 2022
Satoshi Seino, Shoji Shinkai, Akihiko Kitamura, Yu Nofuji, Yuri Yokoyama, Toshiki Hata, Yoshinori Fujiwara   +6 more
doaj   +1 more source