Results 121 to 130 of about 1,068,475 (313)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Development of a prediction model for identifying older adults with low protein using a simple food intake questionnaire

open access: yesJournal of Nutritional Science
Adequate protein intake is crucial for preventing frailty and sarcopenia in older adults, but conventional dietary assessments are time-consuming. Developing a rapid screening tool for identifying those at risk of low protein intake is essential; however,
Yuri Yokoyama   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Active ageing and retiree participation in the Kingdom of Saudi Arabia [PDF]

open access: yes, 2006
This study explores the different ways in which social development in the Kingdom of Saudi Arabia (KSA) can be enhanced by tapping into the experiences and energies of retirees who should be empowered through active participation in society and ...
Al-Shabani, Mohammed A
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Dose–response associations between physical activity and sedentary time with functional disability in older adults with or without frailty: a prospective cohort study

open access: yesFrontiers in Public Health
PurposeEvidence regarding the dose–response curve shapes of physical activity (PA) and sedentary time (ST) in older adults with functional disability (FD) is extremely limited. Moreover, these associations may differ depending on with/without frailty. We
Satoshi Seino   +8 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Participation, growth and social poverty: social capital in a homogeneous society

open access: yes
We introduce social capital accumulation into a neoclassical model, showing how it differs from physical and human capital accumulation. We take the view that social capital is crucial to the enjoyment of socially provided goods and that it is mainly ...
Antoci, Angelo   +2 more
core  

Reflections on participation: Social or sporting capital? [PDF]

open access: yes, 2016
ConnectSport Research Director, Dr Dan Parnell, of the Business School at Manchester Metropolitan University, and Louise Morby, Senior Lecturer in Sport Development at Leeds Beckett University and Equity Lead at the UK Sport Development and Research ...
Parnell, D, Morby, Louise
core  

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