Results 141 to 150 of about 1,068,475 (313)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Promoting Social Participation for Healthy Ageing - A Counterfactual Analysis from the Survey of Health, Ageing, and Retirement in Europe (SHARE) [PDF]

Promoting social participation of the older population (e.g. membership in voluntary associations) is often seen as a promising strategy for 'healthy ageing' in Europe.
Nicolas Sirven, Thierry Debrand
core  

Social cohesion, social trust, social participation and sexual behaviors of adolescents in rural Tanzania

, 2019
Background Social cohesion, defined as a glue holding society together, has been found to influence several aspects of human behavior. Social cohesion, being composed of social trust and social participation, is a social factor that may influence sexual ...
Albino Kalolo, Krumeich, Anja, Jacob Mazalale, Chenault, Michelene, Anja Krumeich, Michelene Chenault, Mazalale, Jacob, Kalolo, Albino   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Rural Community Participation, Social Networks, and Broadband Use: Examples from Localized and National Survey Data

Although attention has been given to how broadband access is related to economic development in rural areas, scant consideration has been given to how it may be associated with voluntary participation.
Boase, Jeffrey, Stern, Michael J., Adams, Alison E.   +2 more
core  

Book review : Community participation, social development and the state by James Midgley

, 1988
Review of: James Midgley. Community participation, social development and the state.
Sanders, Daniel S.
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Socioeconomic Inequity in Access to Medical and Long-Term Care Among Older People

International Journal for Equity in Health
Background Ensuring equitable access to medical and long-term care (LTC) is critical to enable older people to maintain their health and well-being even after they undergo a decline in their intrinsic capacity. Methods We used data from five waves of the
Shohei Okamoto, Atsuhiro Yamada, Erika Kobayashi, Jersey Liang   +3 more
doaj   +1 more source

Patterns of participation: political and social participation in 22 nations [PDF]

, 2008
"Many studies show that political participation at the individual level is fragmented, multidimensional and non-cumulative, but comparison of 22 nations in Europe shows that different kinds of social and political participation at the country level are cumulative, unidimensional. The result is a set of country families of participation.
Newton, Kenneth, Giebler, Heiko
openaire   +2 more sources