Results 41 to 50 of about 1,248,042 (313)

Whose outcomes are they anyway? Report of the pilot evaluation of a joint service\ud [PDF]

, 2011
Health and social care partnership working is often predicated on the notion that it improves outcomes for service users. Yet there is a lack of evidence linking partnerships to changes in outcomes. Against this background, the Health Services Management
Dickinson, Helen, Glasby, Jon, McCarthy,, Linda, Miller, Robin   +3 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Developing the New Kent Complex Psychosis Service (KCPS): Reducing the Limitations Imposed by Treatment-Resistant Psychosis

BJPsych Open
Aims A third to a half of patients with psychosis fail to recover to premorbid levels of functioning. Within these are a group of patients with treatment-resistant psychotic disorders, whose presentations are complex, with significant comorbidities ...
Aderopo Adelola, Eromona Whiskey, Patricia Morgan, Agostina Secchi, Hayley Stentzel   +4 more
doaj   +1 more source

Collaborating to develop : a perspective on current Chinese social partnership development : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Marketing at Massey University, Albany, New Zealand [PDF]

, 2016
In recent years there has been a significant increase in the number of social partnership practices among businesses that are designed to carry out corporate social responsibility. As one of the fastest growing economic regions, domestic Chinese business
Dong, Hua
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Buffalo Arts and Culture Organizations [PDF]

, 2016
Open Buffalo and Partnership for the Public Good collaboratively compiled a directory of organizations that promote social justice through locally based arts and cultural programmatic efforts.
Open Buffalo
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Developing and Integrating Regular Training in Serious Incident Investigations and Coroner’s Inquests Into the Higher Trainees Teaching at Kent and Medway NHS and Social Care Partnership Trust (KMPT)

BJPsych Open
Aims: This project aims to develop and integrate regular training on Serious Incident (SI) Investigations and Coroner’s Inquests into the Higher Trainees Teaching at Kent and Medway NHS and Social Care Partnership Trust (KMPT).
Maria Moisan, Chiara Rubino, Rachel Daly
doaj   +1 more source

Collaborative Funding for Greater Impact: A Case Study of the Cincinnati Experience: Lessons Learned From the Social Innovation Fund [PDF]

, 2012
Offers guidance on grantmaker collaboratives from the city's experience with the Strive Partnership and Cincinnati/Northern Kentucky Social Innovation Fund, including the need for a unifying vision, clear expectations, and maximum funder ...

core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source