Results 61 to 70 of about 222,396 (315)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

How a National Organization Works in Partnership With People Who Have Lived Experience in Mental Health Improvement Programs: Protocol for an Exploratory Case Study [PDF]

Background: This is a research proposal for a case study to explore how a national organization works in partnership with people with lived experience in national mental health improvement programs.
Carina Hibberd, Ashley Shepherd, Ciara Robertson, Robertson, Ciara, Gordon Johnston, Johnston, Gordon, Hibberd, Carina, Shepherd, Ashley   +7 more
core   +1 more source

Understanding the Care Home Psychiatric Service in North Kent

BJPsych Open
Aims: Over 300,000 people in England and Wales reside in care home settings, with a large proportion of these people thought to have memory difficulties.
Emily Pettifor, Mohan Bhat
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Politics and Social Partnership - Flexible Network Governance [PDF]

This paper reassesses the relationship between social partnership and the broader Irish policy process. What has developed may be conceptualised as “flexible network governance”.
Niamh Hardiman
core  

Procyclidine Use in Long-Acting Injectable Antipsychotics

BJPsych Open
Aims: Following a Serious Untoward Incident investigation into a patient death where blood tests revealed procyclidine overdose, significant concerns emerged regarding procyclidine prescribing practices.
Shalina Mitchell, Prabin Gautam
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Civil partnership five years on

, 2011
The Civil Partnership Act 2004, which came into force in December 2005 allowing same-sex couples in the UK to register their relationship for the first time, celebrated its fifth anniversary in December 2010.
Ross, Helen, Gask, Karen, Berrington, Ann   +2 more
core   +1 more source

A Prospective Audit Investigating How the Anticholinergic Effect of Medications on Cognition Is Assessed and Reduced in Patients Admitted to an Older Adult Ward in a Psychiatric Hospital

BJPsych Open
Aims: Older adults often have multiple comorbidities associated with an increased risk of anticholinergic effects. Mental health medications increase this risk, contributing to cognitive decline, dementia, memory loss and confusion.
Dinushi Marambe, Prami Rai
doaj   +1 more source