Results 81 to 90 of about 1,264,953 (363)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Introducing the Dementia Crisis Service in East Kent: Can We Reduce Rates of Hospital Admission?

BJPsych Open
Aims Admissions to hospital can be traumatic for a person with dementia due to an inability to cope with unfamiliar environments, faces and routines.
Swarupa SriBalaskanda, Bastiaan Veugelers   +1 more
doaj   +1 more source

Partnership or PR? Chevron in Bangladesh [PDF]

, 2012
Chevron are investing in communities and promoting human rights in Bangladesh, claiming that partnership with communities is not just good business practice, but crucial for social progress.
Gardner, Katy
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Readmission Patterns to KMPT Acute Wards

BJPsych Open
Aims: To identify patterns of readmission to acute wards and look for specific themes associated with readmissions – discharge planning, diagnosis, gender, social support, accommodation issues and any other associations.
Olubunmi Olure, Valsraj Koravangattu
doaj   +1 more source

Changes in the Relationship between the Outcomes of Cohabiting Partnerships and Fertility among Young British Women: Evidence from the 1958 and 1970 Birth Cohort Studies [PDF]

, 2007
We investigate the effects of a range of time-varying fertility indicators, including pregnancy, and the presence and characteristics of children, on the outcomes of nonmarital unions for two cohorts of British women. We compare the effect of conceptions
Goldstein, Harvey, Joshi, Heather, Kallis, Constantinos, Steele, Fiona   +3 more
core  

A community-based health-social partnership program for community-dwelling older adults: a hybrid effectiveness-implementation pilot study. [PDF]

BMC Geriatr, 2022
Wong AKC, Wong FKY, Wong MCS, Chow KKS, Kwan DKS, Lau DYS.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

STAMP (Supporting Treatment and Appropriate Medication in Paediatrics) to STOMP (Stopping Over Medication of People With a Learning Disability and Autistic People) – A Review of the Demographic and Clinical Characteristics of Transitions From CAMHS to Adult MHLD and Their Outcomes

BJPsych Open
Aims: This study investigates the demographic and clinical characteristics of young individuals (aged 17–24) transitioning from CAMHS (Child and Adolescent Mental Health Service) to Adult MHLD (Mental Health of Learning Disability) services in North Kent.
Sajitha Nair, Mogbeyiteren Eyeoyibo
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source