Results 71 to 80 of about 167,916 (266)

A Systematic Review on the Impact of Mental Health First Aid in Medical, Nursing and Allied Healthcare Professional Students

BJPsych Open
Aims: The unique demands of studying for a healthcare-related degree are associated with an increased risk of developing mental health problems. Stigma and fear of repercussions for their future careers may be a barrier to these students seeking ...
Su Ying Yeoh, Joanne Rodda, Sharna Bennett, Helen Bintley   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Breastfeeding experience, barriers, and facilitators among mothers of vulnerable low birth weight infants in Amhara region, Ethiopia: a qualitative exploratory study

International Breastfeeding Journal
Background Globally, 15 − 20% of all live births are low birthweight (LBW) newborns, and many mothers with LBW newborns experience feeding difficulties.
Moses Collins Ekwueme, Yihenew Alemu Tesfaye, Heran Biza, Mulusew Lijalem Belew, Meseret Asefa, Destaw Asnakew, Abebe Gebremariam Gobezayehu, John Cranmer, Melissa Fox Young   +8 more
doaj   +1 more source

Integrating assessments of secure tenure rights and co-management for small-scale fisheries in seafood sustainability ratings systems: two new scoring methods for FishSource's sustainability assessments

Frontiers in Sustainable Food Systems
Market-based approaches to seafood sustainability have gained popularity in the last decade. Market-based tools, such as certification and ratings systems, enable seafood companies along supply chains to engage in sustainability initiatives while ...
Hugh Govan, Enrique Alonso-Población, Susana Segurado, Rolando Labraña-Cornejo, Pedro Ferreiro-Velasco, Miguel Andreu-Cazenave   +5 more
doaj   +1 more source

SOCIAL PARTNERSHIP IN SOCIAL WORK

Galaxy International Interdisciplinary Research Journal
This is in the article, social affairs about information and social of partnership importance as well as social at work social of partnership positive and negative characteristics about data given passed . Both social of partnership time on demand suitable big features about wide data given passed.
Suyumova Markhabo, M. Abdurakhmonova
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

DONATIONS TO THE KIRILLO-BELOZERSKY MONASTERY AS A REFLECTION OF THE SOCIO-POLITICAL EVOLUTION OF PRINCELY FAMILIES IN THE 16th CENTURY

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. This article analyzes the records of the donation books of the Kirillo-Belozersky Monastery in the context of studying the socio-political evolution of princely families in the Muscovite state of the 16th century. Methods.
Anton Sergeev
doaj   +1 more source