Results 71 to 80 of about 1,264,953 (363)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

For Love and Money: Governance and Social Enterprise [PDF]

, 2007
For Love and Money – Governance and Social Enterprise is the result of research commissioned by the Governance Hub, in partnership with the Social Enterprise Coalition, and conducted by third sector specialists from the Open University. It aims to:
Aiken, Mike, Cornforth, Chris, Spear, Roger   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Prospective Audit Investigating How the Anticholinergic Effect of Medications on Cognition Is Assessed and Reduced in Patients Admitted to an Older Adult Ward in a Psychiatric Hospital

BJPsych Open
Aims: Older adults often have multiple comorbidities associated with an increased risk of anticholinergic effects. Mental health medications increase this risk, contributing to cognitive decline, dementia, memory loss and confusion.
Dinushi Marambe, Prami Rai
doaj   +1 more source

Early Outcomes for Programs and Families in Children's Futures [PDF]

, 2010
Assesses the programmatic achievements and outcomes for families in the first five years of a community change initiative providing an array of social services.
Hillard Pouncy, Jennifer McMaken, John Billings, Karen E. Walker, Reagan M. Daly   +4 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Supporting Non-Psychiatric Trainees to Engage with Reflective Practice and Attend to Their Wellbeing Through Balint Group

BJPsych Open
Aims: Doctors in training report high rates of burnout. The Balint group lends itself to addressing emotional stress and hence the associated risk of burnout. However, Balint group attendance among GP trainees and foundation doctors locally has been poor
Ayatalla Gabre, Elinor Bradley
doaj   +1 more source

Politics and Social Partnership - Flexible Network Governance [PDF]

This paper reassesses the relationship between social partnership and the broader Irish policy process. What has developed may be conceptualised as “flexible network governance”.
Niamh Hardiman
core  

Kent and Medway acute mental health services review [PDF]

, 2012
An independent analysis of the public response to a consultation on ‘achieving excellent care in a mental health crisis’ by the Centre for Nursing and Healthcare Research at the University of Greenwich.
Barshell, Kelly, Chandler, Val, Newton, Paul, West, Elizabeth, Wik, Anna   +4 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source