Results 71 to 80 of about 174,844 (267)

Social partnership - is it 'the only game in town'? [PDF]

Community Development Journal, 2002
Abstact This article attempts to analyse some of the experiences of the Irish community and voluntary sector’s participation in social partnership. The article explores the politics of social partnership and discusses the implications of participation in social partnership for the potential strategies and choices for the community and voluntary sector.
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Systematic Review on the Impact of Mental Health First Aid in Medical, Nursing and Allied Healthcare Professional Students

BJPsych Open
Aims: The unique demands of studying for a healthcare-related degree are associated with an increased risk of developing mental health problems. Stigma and fear of repercussions for their future careers may be a barrier to these students seeking ...
Su Ying Yeoh, Joanne Rodda, Sharna Bennett, Helen Bintley   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Breastfeeding experience, barriers, and facilitators among mothers of vulnerable low birth weight infants in Amhara region, Ethiopia: a qualitative exploratory study

International Breastfeeding Journal
Background Globally, 15 − 20% of all live births are low birthweight (LBW) newborns, and many mothers with LBW newborns experience feeding difficulties.
Moses Collins Ekwueme, Yihenew Alemu Tesfaye, Heran Biza, Mulusew Lijalem Belew, Meseret Asefa, Destaw Asnakew, Abebe Gebremariam Gobezayehu, John Cranmer, Melissa Fox Young   +8 more
doaj   +1 more source

Integrating assessments of secure tenure rights and co-management for small-scale fisheries in seafood sustainability ratings systems: two new scoring methods for FishSource's sustainability assessments

Frontiers in Sustainable Food Systems
Market-based approaches to seafood sustainability have gained popularity in the last decade. Market-based tools, such as certification and ratings systems, enable seafood companies along supply chains to engage in sustainability initiatives while ...
Hugh Govan, Enrique Alonso-Población, Susana Segurado, Rolando Labraña-Cornejo, Pedro Ferreiro-Velasco, Miguel Andreu-Cazenave   +5 more
doaj   +1 more source

SOCIAL PARTNERSHIP IN SOCIAL WORK

Galaxy International Interdisciplinary Research Journal
This is in the article, social affairs about information and social of partnership importance as well as social at work social of partnership positive and negative characteristics about data given passed . Both social of partnership time on demand suitable big features about wide data given passed.
Suyumova Markhabo, M. Abdurakhmonova
openaire   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source