Results 71 to 80 of about 222,396 (315)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Connecticut Behavioral Health Partnership report to the legislature

open access: yes, 2002
"The Departments of Children and Families (DCF), Mental Health and Addiction Services (DMHAS), and Social Services (DSS) have formed the Connecticut Behavioral Health Partnership ..."--P.
Connecticut Behavioral Health Partnership.
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Influencers of effective partnership working between voluntary community sector organisations in Liverpool [PDF]

open access: yes, 2010
With the election of a Coalition Government in May 2010, the concept of “partnership” has never been so prominent in public policy. This builds on a foundation of partnership working playing an increasing role in the policy arena following on from ‘New ...
Wallace, Kathleen
core  

An evaluation of partnership in the development of strategic health policy [PDF]

open access: yes
This PhD analyses strategic health partnerships, focusing on Health Improvement Programmes (HImPs) and Health Action Zones (HAZs). It is a case study of four English health districts, based on 81 semi-structured interviews, and on partnership documents ...
Elston, J
core   +1 more source

Supporting Non-Psychiatric Trainees to Engage with Reflective Practice and Attend to Their Wellbeing Through Balint Group

open access: yesBJPsych Open
Aims: Doctors in training report high rates of burnout. The Balint group lends itself to addressing emotional stress and hence the associated risk of burnout. However, Balint group attendance among GP trainees and foundation doctors locally has been poor
Ayatalla Gabre, Elinor Bradley
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Introducing the Dementia Crisis Service in East Kent: Can We Reduce Rates of Hospital Admission?

open access: yesBJPsych Open
Aims Admissions to hospital can be traumatic for a person with dementia due to an inability to cope with unfamiliar environments, faces and routines.
Swarupa SriBalaskanda   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Participatory Monitoring and Management Partnership

open access: yes, 2015
The Participatory Monitoring and Management Partnership  (PMMP) is an international collaborative network for local leaders and communities working with participatory monitoring and management of natural resources. The Partnership seeks to transform
Participatory Monitoring and Management Partnership
core  

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