Results 71 to 80 of about 336,006 (300)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Trust is fundamental for the stability of human society. A large part of the experimental literature relies on the Trust Game as the workhorse to measure individual differences in trust and trustworthiness.
Carlos Alós-Ferrer, Federica Farolfi
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Social Preferences in Private Decisions [PDF]
SSRN Electronic Journal, 2011 Social preference models were originally constructed to explain two things: why people spend money to affect the earnings of others and why the income of others influences reported happiness. We test these models in a novel experimental situation where participants face a risky decision that affects only their own earnings.
Linde, J., Sonnemans, J.
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Games, 2018 A number of studies discuss whether and how economists differ from other disciplines in the amount that they contribute to public goods. We view this debate as incomplete because it neglects the willingness to sanction non-cooperative behavior, which is ...
Jonas Pilgaard Kaiser +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Cultural Ecosystem Services in Protected Areas: Understanding Bundles, Trade‐Offs, and Synergies
Conservation Letters, 2017 The concept of ecosystem services (ES) provides a potentially useful tool for decision‐making in natural area management. Provisioning and regulating ES often occur in “bundles” that are cohesive because of coprovisioning or codependence.
Judith M. Ament +3 more
doaj +1 more source
Beliefs and social behavior in a multi-period ultimatum game
Frontiers in Behavioral Neuroscience, 2015 We conduct a multi-period ultimatum game in which we elicit players’ beliefs. Responders do not predict accurately the amount that will be offered to them, and do not get better in their predictions over time.
Ofer Haim Azar +2 more
doaj +1 more source