Results 51 to 60 of about 5,389,679 (340)

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Contemporary Limitations to Religious Solutions to Social Problems [PDF]

open access: yes, 2014
Religion has contributed immensely to solving some of the social problems. The aim of this paper is to situate social problems within the context of other variables like human nature, plurality of cultures, and diversity in hermeneutics of societal ...
Duke, Emmanuel Orok
core  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

System Transformation: Achievements and Social Problems in Poland [PDF]

open access: yes, 2015
The present book “Poland – History, Culture and Society. Selected Readings” is the third edition of a collection of academic texts written with the intention to accompany the module by providing incoming students with teaching materials that will assist ...
Warzywoda-Kruszyńska, Wielisława
core  

Trauma from Armed Conflict and the Effect on Mental Health in Thailand's Deep South: A Systematic Review [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Introduction: The Deep South region of Thailand has faced a situation of jihadist insurgency since 2004 with indiscriminate attacks on civilians and more than 19,000 casualties as of September 2016.
Wit Wichaidit
doaj   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Social interaction as a heuristic for combinatorial optimization problems

open access: yes, 2010
We investigate the performance of a variant of Axelrod's model for dissemination of culture - the Adaptive Culture Heuristic (ACH) - on solving an NP-Complete optimization problem, namely, the classification of binary input patterns of size $F$ by a ...
Fontanari, Jose F.
core   +1 more source

Intercompany training as production pedagogical process

open access: yesВестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016
The article explains the corporate training as a coordinated interaction of educational and industrial processes in the preparation of in-demand professionals.
Evgeny A. Korchagin   +2 more
doaj  

“Failures of the State”: Factors of Formation and Mechanisms of Influence on Economic Processes

open access: yesVestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 3, Èkonomika,Èkologiâ, 2014
The article is devoted to the problem of genesis and influence on real economic processes of “failures of the state”. The article designates the objective functions inherent in the state the realization of which can increase the efficiency of economic ...
Gontar Nikolay Vladimirovich
doaj   +1 more source

Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa   +2 more
wiley   +1 more source

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