Results 51 to 60 of about 24,725,815 (337)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The Problem of Social Protection in Albania [PDF]
, 2013 The aim of this paper is to analyze the social protection system in Albania during the last two decades. It highlights some of the problems and issues which are closely associated with elements of social security, as a phenomenon that focuses on finding ...
Dragoshi, Gert, Shkreli Axhemi, Arlinda
core +2 more sources
Prace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego, 2019 The report provides an assessment of the innovation factor in the reindustrialisation of Eastern Siberia, based on data on R&D costs and the introduction of innovative products. The Krasnoyarsk Territory has the greatest innovative potential, followed by
Vera Rudneva
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
BMC Psychiatry, 2018 BackgroundThe adverse effects of loneliness and of poor perceived social support on physical health and mortality are established, but no systematic synthesis is available of their relationship with the outcomes of mental health problems over time.
Jingyi Wang +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Parameterized Algorithmics for Computational Social Choice: Nine Research Challenges [PDF]
, 2014 Computational Social Choice is an interdisciplinary research area involving Economics, Political Science, and Social Science on the one side, and Mathematics and Computer Science (including Artificial Intelligence and Multiagent Systems) on the other ...
Bredereck, Robert +5 more
core +3 more sources
Intercompany training as production pedagogical process
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016 The article explains the corporate training as a coordinated interaction of educational and industrial processes in the preparation of in-demand professionals.
Evgeny A. Korchagin +2 more
doaj
Russia, China: Poverty Alleviation (Comparative Analysis)
Управленческое консультирование, 2020 Goal and objectives. The article analyzes the state policy of Russia and China on poverty alleviation, conducted a comparative analysis of the strategy of the two countries in solving the problem, basic areas, social programs, measures, measures of ...
I. S. Orlova, G. M. Tsinchenko
doaj +1 more source