Results 111 to 120 of about 3,033,607 (304)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

DEMOGRAPHIC AND LABOUR FORCE AGEING – RISK FACTORS FOR THE SOCIAL PROTECTION SYSTEM IN ROMANIA [PDF]

open access: yes
Population ageing is one of the main challenges to the economic and social development in the next decades. This article examines the main implications of demographic and labour force ageing on the future of social protection in Romania.
Maria POENARU
core  

Social protection [PDF]

open access: yes, 2008
Conventional wisdom in European studies has long held that social policy is not an area in which the European Union can make a large difference. Solidarity, it is said, can only develop in societies where clear boundaries exist between individuals.
Dehousse, Renaud
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

CPD curriculum guide for social workers who are working with people on the autism spectrum [PDF]

open access: yes, 2015
Tizard Centre, Centre for Child Protection (2015) “A report on autism for social workers” Commissioned by The College of Social Work (written and published by the Dept.
Reeves, Jane
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Aspects of Non-Standard Employment in Europe [PDF]

open access: yes, 2017
[Excerpt] This report investigates recent developments in non-standard employment in the European Union. While the overall policy context is ‘social protection for all’, it does not focus exclusively on social protection.
Eurofound
core   +1 more source

Flexicurity strategies on the economic crisis background

open access: yesAnnals of Spiru Haret University Economic Series, 2010
• The flexicurity concept – a combination of flexibility and security strategies, specific to each country – is a successful outcome[1] of the 2010 Lisbon Strategy.
Daniela PAŞNICU, Luise MLADEN
doaj  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy