Results 101 to 110 of about 13,987,184 (247)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Flexicurity strategies on the economic crisis background
Annals of Spiru Haret University Economic Series, 2010 • The flexicurity concept – a combination of flexibility and security strategies, specific to each country – is a successful outcome[1] of the 2010 Lisbon Strategy.
Daniela PAŞNICU, Luise MLADEN
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
How to design gender-sensitive social protection systems
, 2021 This is the sixth in a series of policy primers developed to support policymakers and practitioners in Asia and the Pacific in their efforts to strengthen social protection.
UN.ESCAP
core +1 more source
Сибирский научный медицинский журналMalignant neoplasms of the colon are one of the most common oncological diseases in the world, characterized by a high incidence of morbidity and mortality. This disease has a significant impact on the quality of life, often leading to disability.
E. A. Shuykova +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The scope of social protection in this report refers to the extension of measures to provide basic income security for all. This report also addresses the role of social protection in dealing with the impact of climate change in Thailand, which has ...
United Nations Resident Coordinator Office (UNRCO) +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Social inclusion report: incorporating annual reports for 2009 and 2010 [PDF]
, 2012 The National Action Plan for Social Inclusion 2007 to 2016 (NAPinclusion), was launched in February 2007. It sets out a wide ranging and comprehensive programme of action to tackle poverty and social exclusion.
Department of Social Protection
core