Results 81 to 90 of about 3,033,607 (304)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Stratification and Inequality in the Secondary Education System in Romania

Systems
Education is a complex system with implications for educational policy and management. Education systems that are more comprehensive generate more equal outcomes, fostering access to opportunities for all children.
Ana-Maria Zamfir, Anamaria Beatrice Aldea, Raluca-Mihaela Molea   +2 more
doaj   +1 more source

Epidemiology and control of malaria in Colombia

Memorias do Instituto Oswaldo Cruz, 2011
Malaria is currently one of the most serious public health problems in Colombia with an endemic/epidemic transmission pattern that has maintained endemic levels and an average of 105,000 annual clinical cases being reported over the last five years ...
Julio Cesar Padilla Rodríguez, Gilberto Álvarez Uribe, Roberto Montoya Araújo, Pablo Chaparro Narváez, Sócrates Herrera Valencia   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Social Protection, Efficiency and Growth [PDF]

Social protection can play an important role in poverty reduction and making growth inclusive of the poor. At times, it is also argued that social proection can directly contribute to growth and economic efficiency. The paper revisits the evidence on the
Stefan Dercon
core  

Making National Social Protection Floors Work for Women [PDF]

, 2015
This brief synthesizes research findings, analysis and policy recommendations on making social protection floors work for women. The idea of a social protection floor (SPF) is now firmly established on the global development agenda.
Silke Staab
core  

Do behavioral drivers matter for healthcare decision-making during crises? A study of low-income women in El Salvador during the COVID-19 pandemic

BMC Public Health
Understanding health-seeking behaviors and their drivers is key for governments to manage health policies. A growing body of research explores the role of cognitive biases and heuristics in health and care-seeking behaviors, but little is known about how
Pedro Bernal Lara, Giuliana Daga, Lajos Kossuth, Florencia Lopez Boo   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Social Protection Support Project in the Philippines [PDF]

, 2015
Key Points The Pantawid Pamilya conditional cash transfer program reached more than 4.4 million poor families in 2014. Rigorous impact evaluation in 2012 and 2014 confirms that Pantawid Pamilya improves access to health services, keeps children in ...
Schelzig, Karin
core   +1 more source