Results 21 to 30 of about 421,015 (257)

Impact of mobile phones on HIV public stigma: a cross-sectional and pseudo-panel analysis from Ghana

BMJ Open, 2022
Objective HIV-related stigma still remains a major barrier to testing and a significant burden for people living with HIV (PLWH) in sub-Saharan Africa. This paper investigates how mobile phone ownership can influence HIV-related stigma.Design This is an ...
Francesco Iacoella, Franziska Gassmann, Nyasha Tirivayi   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Experiences of child street beggars in inner-city Accra, Ghana

Discover Social Science and Health
Background The phenomenon of child begging has emerged as a visible and deeply troubling aspect of urban poverty worldwide, particularly in low- and middle-income countries.
Sylvester Kyei-Gyamfi, Frank Kyei-Arthur, Joseph Kwatsenu, Abigail A. Tetteh-Yankey, Joseph Martey Otchere, Kelvin Kwaku Aduful, Maame Adwoa Nyame Sam, Kingsley Osei-Owusu, Prince Boamah Abrah, Abena Dufie Akonu-Atta, Sena Owusu-Gibson, Godwin Appiah-Kubi   +11 more
doaj   +1 more source

The Opportunities of Formation of Effective Functioning Social Protection System in RA

Banber Erevani Hamalsarani. Sots'iologia, 2017
The article presents the main problems impeding the formation of effective functioning social protection system in RA.
Marine Yarmaloyan
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Correlations between Expenditure and Employees in R&D Activity by Performance Sectors from Romania [PDF]

Revista Română de Statistică, 2016
In the context of increased competition in the recent years, the innovation has become a key factor in economic development through better use of opportunities, capturing new markets and creating high quality jobs.
Vasilica Ciucă , Daniela Pașnicu, Gabriela Tudose , Mihai Robert Paşnicu   +3 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quality of Employment in Small and Medium Enterprises in Romania [PDF]

Revista de Management Comparat International, 2018
In this article we propose to discuss the quality of employment in SMEs in Romania. We have debated the role of small and medium-sized enterprises in the Romanian economy, public policy proposals to create an ecosystem that promotes transformation of ...
Daniela PASNICU, Ghenadie CIOBANU
doaj   +1 more source