Results 131 to 140 of about 2,062,933 (307)
Adults in further education: A policy overview [PDF]
, 2009 Policy on FE is aimed at tackling social exclusion and contributing to economic efficiency. Several measures have contributed to increasing both participation and achievements of adults yet the needs of many of the most disadvantaged adults remain unmet.
Finlay, Ian
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Why Care? Social Norms, Relative Income and the Supply of Unpaid Care [PDF]
We focus on the role of conformity with social norms and concern with relative income in the decision to supply unpaid care for parents. Individuals have different propensities to be influenced by both relative income and social norms, and face a time ...
Marina Della Giusta +2 more
core
More Law than Politics: The Chief, the “Mandate,” Legality, and Statesmanship [PDF]
, 2013 This chapter in a forthcoming book on NFIB v. Sebelius asks whether the various parts of Chief Justice Roberts’s opinion on the minimum coverage provision are legally justifiable. I focus on what Roberts decided, not why he decided it that way.
Siegel, Neil S.
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Social Innovation in the Provision of Services in Long-term Care
European Journal of Mental Health, 2017 Zsuzsa Széman, Anett Mária Tróbert
doaj +1 more source
Evaluation of European Social Fund Priority 1 and Priority 4: extending employment opportunities to adults and young people [PDF]
, 2011 This evaluation report forms part of a suite of research gathering evidence on the delivery of the European Social Fund (ESF). It aims to improve understanding of the processes, range and delivery of ESF Priority 1 and Priority 4 provision within the ...
Atkinson, Ian
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source