Results 51 to 60 of about 125,898 (258)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Du capital social à la soutenabilité sociale : enseignements d’une démarche locale de construction d’indicateurs de bien-être soutenable

Développement Durable et Territoires, 2016
Based on the IBEST (“indicateurs de bien-être soutenable” in French) project, which focuses on the construction of sustainable territorial social indicators in the urban community of Grenoble, this article questions the operationality and the ...
Anne Le Roy, Fiona Ottaviani
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Unintended consequences: data practice in the backstage of social media

The Journal of Chinese Sociology
Through an ethnographic study of Chinese IT professionals who integrate a form of data culture into the digital platforms they design, maintain, and operate daily within one of China’s tech giants, this paper reveals numerous overlaps and interrelations ...
Ken Zheng
doaj   +1 more source

QUANTITATIVE METHODS AND RESEARCH IN SOCIAL SCIENCE: LOGIC AND UTILITY OF THE USE OF QUANTIFICATION IN THE EXPLANATIONS OF SOCIAL PHENOMENA

Mediações: Revista de Ciências Sociais, 2013
The article presents a theoretical analysis on methodological foundations (not only procedural) of so-called "quantitative methods" in social science research, which are often – but mistakenly – reduced to the idea of "quantification techniques".
Marília Patta Ramos
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Quantification of shared air: a social and environmental determinant of airborne disease transmission.

PLoS ONE, 2014
BackgroundTuberculosis is endemic in Cape Town, South Africa where a majority of the population become tuberculosis infected before adulthood. While social contact patterns impacting tuberculosis and other respiratory disease spread have been studied ...
Robin Wood, Carl Morrow, Samuel Ginsberg, Elizabeth Piccoli, Darryl Kalil, Angelina Sassi, Rochelle P Walensky, Jason R Andrews   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Validation of a Headspace Gas Chromatography with Flame Ionization Detection Method to Quantify Blood Alcohol Concentration (BAC) for Forensic Practice

Chemosensors
Alcohol consumption is a major social and forensic issue. It is often the cause of road accidents, industrial accidents, suicides and other crimes. On account of this, it is of fundamental importance in forensic toxicology to correctly quantify blood ...
Alice Cerioni, Gianmario Mietti, Marta Cippitelli, Giulia Ricchezze, Erika Buratti, Rino Froldi, Mariano Cingolani, Roberto Scendoni   +7 more
doaj   +1 more source

Efficiency in Social Enterprises

Multidisciplinary Journal for Education, Social and Technological Sciences, 2017
The aim of this article is to offer a review of the impact the different methodologies of analysis have on social enterprises, focusing the study on processes that establish a greater universality based on the degree of success achieved in their social ...
José Carlos Ballester-Miquel, Pilar Perez-Ruiz, Javier Hernandez-Gadea, Hugo De juan Jordán, Maria Guijarro García   +4 more
doaj   +1 more source