Results 81 to 90 of about 125,898 (258)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The social sciences of quantification

Bibliothèque Georges Lefebvre – Institut de recherches historiques du Septentrion, 2016
  +4 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Social vulnerability and media analysis of hydrological disasters in the province of Entre Ríos, Argentina (2000-2020)

Revista de Estudios Latinoamericanos sobre Reducción del Riesgo de Desastres
Social vulnerability allows establishing structural conditions of populations in territories at risk of disaster. The understanding of these situations is complemented through the quantification of extreme hydrological events reported by the media, when ...
Ricardo Castro-Díaz, María Laura Visintini, María Laura Visintini, Manuel del Rey Rodríguez, Manuel del Rey Rodríguez, María Belén Bustamante, María Belén Bustamante, Melissa Anabella Medrano, Melissa Anabella Medrano, Mercedes Müller Heidenreich, Mercedes Müller Heidenreich, Claudia E. Natenzon, Claudia E. Natenzon   +12 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Functional loss quantification of post-disaster thermal power plants: Functional state function method

Resilient Cities and Structures
Power plants are important lifeline engineering in urban construction. To improve their sustaining ability, adaptability, and recovery capabilities to uncertain hazards, it is vital for realizing engineering resilience, which contributes the reduction of
Yongbin Liu, Hongxing Li, Ying Zhou, Jiangwen Song, Dong Jiang, Xianan Hou, Zheng Cheng, Yiqiu Lu   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Sociology of Quantification – Perspectives on an Emerging Field in the Social Sciences

, 2016
The introductory article to this HSR Special Issue presents the emerging field of sociology of quantification, which can be regarded as a transdisciplinary approach to the analysis of processes of quantification. Processes of categorization and classification are included because they can result in processes of generating figures and numbers also.
Diaz-Bone, Rainer, Didier, Emmanuel
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Les enjeux de la quantification sanitaire au XXe siècle

Histoire, Médecine et Santé, 2013
Bruno Valat
doaj   +1 more source