Exploring the Relationship between Membership Turnover and Productivity in Online Communities
, 2014 One of the more disruptive reforms associated with the modern Internet is the emergence of online communities working together on knowledge artefacts such as Wikipedia and OpenStreetMap.
Cunningham, Pádraig +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The School of Thought: Relational Processes of Lasting Existence and Transformation
Nauki o Wychowaniu, 2019 This article is an attempt to analyze the features of the titular concept of the school of thought, which occurs through participation in situations that encourage the sharing of experience.
Ewa Marynowicz-Hetka
doaj +1 more source
Predeath Grief, Resourcefulness, and Perceived Stress Among Caregivers of Partners With Young-Onset Dementia [PDF]
, 2019 More than 200,000 Americans are currently diagnosed with young-onset dementia (YOD). YOD is dementia diagnosed prior to the age of 65. Most persons of YOD are cared for by their partners.
Bekhet, Abir K. +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Social relationships among adolescents as described in an electronic diary: a mixed methods study
Patient Preference and Adherence, 2017 Katriina I Anttila,1,2 Minna J Anttila,1 Marjo H Kurki,1 Maritta A Välimäki1,3,4 1Department of Nursing Science, University of Turku, Turku, 2Helsinki University Hospital, Children and Adolescents, Child Psychiatry, Helsinki, 3Turku University
Anttila KI +3 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The importance of social relationships in depression in autistic adolescents: a narrative-review
Frontiers in PsychologyObjectiveThe impact of social relationships on autistic adolescents has been recently studied. However, the link between social relationships and depression in autistic adolescents seem underrepresented in the scientific literature.
Élise Mamimoué +3 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source