Results 121 to 130 of about 6,260,344 (295)
The co-evolution of emotional well-being with weak and strong friendship ties
, 2017 Social ties are strongly related to well-being. But what characterizes this relationship? This study investigates social mechanisms explaining how social ties affect well-being through social integration and social influence, and how well-being affects ...
Boda, Zsofia +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Meaning of Sekura Cakak Buah Tradition of Saibatin Community
Jurnal Pendidikan Humaniora, 2020 : Sekura Cakak Buah is the oldest tradition of saibatin community in Lampung Barat regency. The tradition that were born and developed in tandem with the civilization of the people certainly have profound meaning and values. This research aims to uncover
Eka Purnama Sari +2 more
doaj
Social Capital, Well-Being, and Earnings: Theory and Evidence from Poland [PDF]
We study the relationship between two distinct dimensions of social capital (bridging and bonding social capital) and the personal performances of individuals: their reported subjective well-being (SWB) and earnings.
Growiec, Jakub, Growiec, Katarzyna
core +1 more source
Inequality and Economic Prosperity: What Accounts for Social Justice and Inclusive Growth? Bertelsmann Stiftung Impulse #2015/03 [PDF]
, 2015 There is much debate nowadays on the massive problem of rising social and economic inequalities. Many studies criticize the disturbingly unequal distribution of income and wealth – within nations and across countries.
Schraad-Tischler, Daniel
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Social relationship provisions and loneliness in school: Child- and classroom-level effects. [PDF]
J Sch Psychol, 2023 Yust PKS +3 more
europepmc +1 more source