Results 91 to 100 of about 2,410,903 (293)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A mixed effects model for longitudinal relational and network data, with applications to international trade and conflict

, 2011
The focus of this paper is an approach to the modeling of longitudinal social network or relational data. Such data arise from measurements on pairs of objects or actors made at regular temporal intervals, resulting in a social network for each point in ...
Hoff, Peter D., Westveld, Anton H.
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Framing children's citizenship: exploring the space of children's claims for social justice using Nancy Fraser's conception of representation [PDF]

, 2012
This paper seeks to contribute to a dynamic understanding of the space of children‟s citizenship by exploring perspectives generated by children age 5-13 in two countries in the light of Nancy Fraser‟s (2008) theory of representation.
Larkins, Cath
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Spectacular Tropes: Representations of the Roman Arena [PDF]

, 2018
This paper will focus on the construction of representational tropes depicting the ancient Roman arenas and those involved with them, particularly within the spectacles of gladiatorial battles.
Britt, Tiger Maurice
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Aids’s Images and Meanings Among Users of the Health Basic Net Services of the Rio de Janeiro County

Psicologia, 2009
The present work aimed at identifying and describing the images and the meanings present in the Aids ́s social representations among women attended in the health basic net. It is a qualitative study based on the social representations theory.
Sérgio Corrêa Marques, Maria Antonieta Rubio Tyrrell, Denize Cristina de Oliveira   +2 more
doaj  

Afetos e representações sociais: contribuições de um diálogo transdisciplinar

Psicologia: Teoria e Pesquisa
Este texto é resultado de uma pesquisa teórica cujos objetivos foram: explorar a afinidade entre a Teoria do Desenvolvimento Emocional, de Winnicott, e a Teoria das Representações Sociais, de Moscovici, e indicar o papel da afetividade na construção de ...
Carolina Fernandes Pombo-de-Barros, Angela Maria Silva Arruda   +1 more
doaj   +1 more source