Results 121 to 130 of about 9,272,150 (305)
Enfances, Familles, Générations, 2010 Establishing the fact of incapacity is both a legal and a clinical process, overseen by laws and professional standards that establish a requirement to consult with family and those closely connected to the individual whose capacities are being assessed.
Catherine Canuel +2 more
doaj
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Psicologia: Ciência e ProfissãoEste trabalho objetivou explorar as representações, compartilhadas por vinte e cinco profissionais da educação da rede regular de ensino fundamental, acerca da inclusão escolar de alunos com necessidades especiais.
Claudia Gomes +1 more
doaj
Enfances, Familles, Générations, 2019 Research Framework : In child psychiatric hospitalization services, the bodies of adolescents are suddenly extracted from the public sphere in which they should normally be.
Cristina Figueiredo
doaj
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Père au foyer : une nouvelle entrée au répertoire du masculin ?
Enfances, Familles, Générations, 2017 Research Framework: Despite advocacy in favour of the equal sharing of domestic labour and family responsibilities, women are still overwhelmingly in charge of childcare and housework; for a man to become a “stay-at-home father” is a reversal of ...
Myriam Chatot
doaj
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
[Children's social representation of cancer].
Revista da Escola de Enfermagem da U S P, 2004 This research was motivated by the need to know more about the care of children with cancer. The objective of the study was to discover what the social representation of the child with cancer are. Ten open interviews were conducted with children and teenagers from 9 to 15 years of age. The analysis issues that emerged from the children's discourse were
Cagnin, Elaise Regina Gonçalves +2 more
openaire +2 more sources