Results 131 to 140 of about 9,372,448 (341)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Violent social norms: a study on the symbolic elaboration of violence in adolescents / Norma social violenta: um estudo da representação social da violência em adolescentes

Psicologia: Reflexão e Crítica, 2007
The present work approaches teenage violence, exploring the consensual field of social representation and identifying some elements that act as guiders and justifiers of violent action.
Silvia Pereira Guimarães, Pedro Humberto Faria Campos   +1 more
doaj  

Remembering and belonging : colonial settlers in New Zealand museums : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University [PDF]

, 2007
This study approaches museums as socially constructed signifiers of group identities. Focusing specifically on museological representations of colonial settlers at museums and historical sites in New Zealand, I analyse how this group is constructed in ...
Wirick, Esther Lucia
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

From representations to representing: On social representations and discursive-rhetorical psychology [PDF]

, 2015
Gibson, Stephen
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Sintomatologia depressiva em adolescentes do ensino médio: um estudo das representações sociais

Psicologia: Ciência e Profissão
A depressão é uma das psicopatologias que vêm avançando nas demandas da saúde coletiva e ocorre em qualquer idade, independentemente da inserção socioeconômica e cultural. O presente trabalho teve como objetivo apreender as representações sociais (RS) da
Fabiana Ribeiro Monteiro, Maria da Penha de Lima Coutinho, Ludgleydson Fernandes de Araújo   +2 more
doaj   +1 more source

Social representations of nutrition: proposal production of teaching materials chemistry [PDF]

Investigações em Ensino de Ciências, 2013
In this paper, we present the stages of production of didactic material of Chemistry (thematic unit on nutrition), and the results of its application in a classroom of basic education.
Carlos Ventura Fonseca , Rochele de Quadros Loguercio   +1 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source