Results 61 to 70 of about 1,403,691 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Medium-scale commercial agriculture and its role in structural transformation, wealth creation and enhanced livelihoods in an African context: Evidence from contemporary Zimbabwe

African Journal on Land Policy and Geospatial Sciences
This paper investigates the extent to which Zimbabwe’s emergent medium-scale commercial farms have the potential to contribute to structural transformation, wealth creation and enhanced livelihoods.
Clement Chipenda
doaj   +1 more source

Trabajo doméstico y de cuidado no remunerado. ¿Quién asume el costo de la reproducción social?

ILCEA, 2018
Unpaid domestic work is responsible for social reproduction whose cost must be assumed through public policies by the State, from the perspective of feminist economics.
Alicia Girón
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Aspects of Sex Differences: Social Intelligence vs. Creative Intelligence [PDF]

, 2017
In this article, we argue that there is an essential difference between social intelligence and creative intelligence, and that they have their foundation in human sexuality.
Fellmann, Ferdinand, Redolfi Widmann, Esther   +1 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Capitalist Reproduction in Schooling: The social control of marginalized students through zero tolerance policies [PDF]

, 2019
Due to increasing media focus, there has been growing concern that U.S. students and the school environment are increasingly violent, leading the public to believe that school discipline should become more strict and punitive (Giroux 2003; Schept, Wall, &
Wickline, Mary K
core   +1 more source

Saving and reproducing the nation: Struggles around right-wing politics of social reproduction, gender and race in austerity Europe [PDF]

, 2018
This article suggests the analytic lens of cultural, social and national reproduction to understand the centrality of gendered and ethnic relations, in particular a focus on family life in contemporary UK.
Ahmed, Albanese, Alexander, Andrews, Balibar, BBC, Berkovitch, Bezanson, Bhabha, Bhambra, Blom, Blum, Bonizzoni, Bourdieu, Bourdieu, Cameron, Cantle, Children’s Commissioner, Daily Mail, Doty, Dummett, El-Tayeb, Emejulu, Erel, Erel, Erel, Fortier, Fraser, Gramsci, Gutiérrez Rodríguez, Gutiérrez Rodríguez, Hage, Home Office, Institute of Race Relations, Jayawerdena, Jensen, Keskinen, Khan, Kirkup, Kofman, Kofman, Kováts, Kraler, Lareau, Luxton, Mayer, McClintock, McDonagh, Mosse, Mulinari, Pető, Phoenix, Price, Rattansi, Reynolds, Scott, Sirriyeh, Smith, Spierings, The Independent, Topping, Turner, Turner, Umut Erel, Vacchelli, Virdee, Wearing, Weaver, Women's Budget Group, Women's Budget Group and Runnymede Trust, Yuval-Davis, Yuval-Davis   +71 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source