Results 61 to 70 of about 2,929,136 (354)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Corporate Social Responsibility

open access: yesSSRN Electronic Journal, 2022
Is shareholder interest in corporate social responsibility driven by pecuniary motives (abnormal rates of return) or nonpecuniary ones (willingness to sacrifice returns to address various firm externalities)? To answer this question, we summarize the literature by focusing on seven tests: ( a) costs of capital, ( b) performance of portfolios, ( c ...
Harrison G. Hong, Edward P. Shore
openaire   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Social Responsibilities

open access: yes, 2020
Published
Dr. T.X.A. Ananth   +2 more
openaire   +2 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren   +16 more
wiley   +1 more source

Gauging the impact of community university engagement initiatives in India

open access: yesASEAN Journal of Community Engagement, 2017
Today, the world we live inis challenged with the co-existence of ‘prosperity and poverty’. In India, inparticular, although we are witnessing staggering increase in various economicindicators, our Human Development Indicators (HDIs) remain unenviable ...
Wafa Singh
doaj   +1 more source

Responsibility: Social

open access: yes, 2014
The concept of ‘social responsibility’ has first come into use with reference to the actors of economic activity and the various interests and needs of the stakeholders, i.e. the many individuals and organizations on which the actions of a company or a corporation have an impact.
openaire   +3 more sources

Are Corporations Socially Responsible? Is Corporate Social Responsibility Desirable? [PDF]

open access: yesBond Law Review, 1992
extract] It is submitted that (for the reasons outlined in Part One) corporations have, at the most, only limited opportunities for pursuing CSR [corporate social responsibility]. Further (for the reasons outlined in Part Two), it is submitted that corporations should not engage in CSR.
openaire   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Reasserting Gija women's role in mine site reclamation: A perspective from the Argyle Diamond Mine

open access: yesJournal of Political Ecology
The Argyle diamond mine, in the East Kimberley region of Western Australia, ceased production in late 2020 after 37 years of operations and producing 865 million carats of rough diamonds.
Kia Dowell, Sarah Elizabeth Holcombe
doaj   +2 more sources

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