Results 61 to 70 of about 8,174,087 (362)
Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase
FEBS Letters, EarlyView.The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Gauging the impact of community university engagement initiatives in India
ASEAN Journal of Community Engagement, 2017 Today, the world we live inis challenged with the co-existence of ‘prosperity and poverty’. In India, inparticular, although we are witnessing staggering increase in various economicindicators, our Human Development Indicators (HDIs) remain unenviable ...
Wafa Singh
doaj +1 more source
Institutional Shareholders and Corporate Social Responsibility
Journal of Financial Economics, 2019 This study uses two distinct quasi-natural experiments to examine the effect of institutional shareholders on corporate social responsibility (CSR). We first find that an exogenous increase in institutional holding caused by Russell Index reconstitutions
Tao Chen, Huiyan Dong, Chen Lin
semanticscholar +1 more source
, 2014 The concept of ‘social responsibility’ has first come into use with reference to the actors of economic activity and the various interests and needs of the stakeholders, i.e. the many individuals and organizations on which the actions of a company or a corporation have an impact.
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Resources, 2017 Regional planning approaches to mining infrastructure aim to reduce the conflict associated with mining operations and existing land uses, such as urban areas and biodiversity conservation, as well as the cumulative impacts that occur offsite.
Alex M. Lechner +8 more
doaj +1 more source
Corporate Social Responsibility during COVID-19 Pandemic
Journal of Open Innovation: Technology, Market and Complexity, 2020 The health, economic, and social consequences of the SARS-CoV-2 virus have highlighted the need for collaboration among all agents to face a scenario that we have not before seen. The aims of this paper are to analyze the involvement that large Spanish
Isabel‐María García‐Sánchez +1 more
semanticscholar +1 more source