Results 151 to 160 of about 13,797,006 (300)
Deflation of Rights Amidst the Cost-of-Living Crisis in England: Submission to the European Committee of Social Rights [PDF]
This report responds to the call for evidence from the European Committee of Social Rights by addressing the cost-of-living crisis in England. It examines the impact of the crisis on socio-economic rights within the context of England's social security ...
Casla, Koldo, Barker, Lyle
core +1 more source
What Drives Opposition to Social Rights for Immigrants? Clarifying the Role of Psychological Predispositions. [PDF]
Polit Stud (Oxf)Knotz CM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Wrongs and rights: the economic, social and cultural rights of Indigenous peoples in Australia
, 2003 [Introduction]: This 'Wrongs and Rights' report provides an overview of recent research into Aboriginal and Torres Strait Islander peoples in Australia as at 2001, based on a number of economic and social welfare indicators, including health, education ...
Jones, Nicky
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Caring for rights : social work and advocacy with looked after children and young people [PDF]
This thesis concerns young people in the Midlands area of the United Kingdom and the services they receive from children’s rights workers and social workers.
Barnes, K. Vivienne (Kathryn Vivienne)
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source