Results 141 to 150 of about 3,546,996 (310)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

EL SISTEMA EUROPEO DE DERECHOS FUNDAMENTALES TRAS LA ENTRADA EN VIGOR DEL TRATADO DE LISBOA

open access: yesLex Humana, 2011
Resumen: En 1947 se pusieron las bases de lo que llegaría a ser la Unión Europea, a modo de organización comercial para sectores concretos, complejo que iría creciendo, ampliándose los fines y la organización, a la par que se fraguaba un complejo ...
Lorenzo Martín-Retortillo Baquer
doaj  

Mobilising social rights

open access: yes, 2023
The European Pillar of Social Rights (EPSR) sits at the fulcrum of EU social policy-making. As a formally non-binding interinstitutional proclamation composed of 20 social rights and principles, its (potential) effects are far from clear. Through a comprehensive empirical study, this thesis explores the effects of the EPSR on policy instruments ...
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

"Women's Rights as Human Rights: A Political and Social Economy Approach within a Deep Democratic Framework" [PDF]

open access: yes
In this paper we offer the social capabilities based approach to women's rights as human rights. We begin with the standard approach and discuss the universal human rights model before developing the social capabilities approach followed throughout the ...
Haider A. Khan
core  

What is become of the rights of men? : are you the only men who have rights? ; moral contractarianism and the legitimation of universal human rights [PDF]

open access: yes, 2012
In this article I advance an account of human rights as individual claims that can be justified within the conceptual framework of social contract theories. The contractarian approach at issue here aims, initially, at a justification of morality at large,
Araujo, Marcelo de
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

WHO OWNS NATURAL RESOURCES IN THE UNITED STATES AND CANADA? [PDF]

open access: yes
Property rights are social definitions; they exist as long as the society is willing to enforce them. If enforcement is missing, they cease to exist.
Marchak, M. Patricia
core   +1 more source

Collective Management of Copyrights and Human Rights: An Uneasy Alliance Revisited [PDF]

open access: yes, 2010
This essay analyzes the “creators’ rights” provisions of the International Covenant on Economic Social and Cultural Rights (ICESCR) in the context of the collective administration of copyright and neighboring rights and the policies and practices of ...
Helfer, Laurence R.
core   +1 more source

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