Results 121 to 130 of about 610,169 (309)
International Journal of Constitutional LawAbstract This Foreword revisits the commonly understood origin story of social rights and the social constitution. It challenges the predominant thesis that social rights were a conceptual by-product of the rise of the welfare state. Instead, it argues that, in the nineteenth century, social rights—which have longer and deeper historical
openaire +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Wrongs and rights: the economic, social and cultural rights of Indigenous peoples in Australia
, 2003 [Introduction]: This 'Wrongs and Rights' report provides an overview of recent research into Aboriginal and Torres Strait Islander peoples in Australia as at 2001, based on a number of economic and social welfare indicators, including health, education ...
Jones, Nicky
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Deflation of Rights Amidst the Cost-of-Living Crisis in England: Submission to the European Committee of Social Rights [PDF]
This report responds to the call for evidence from the European Committee of Social Rights by addressing the cost-of-living crisis in England. It examines the impact of the crisis on socio-economic rights within the context of England's social security ...
Casla, Koldo, Barker, Lyle
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Hong Kong and the implementation of the International Covenant on Economic, Social and Cultural Rights [PDF]
, 1994 published_or_final_versionContributorsThe international covenant on economic, social and cultural rights and the work of the committee on economic, social and cultural rights Bonoan-Dandan, Virginia Bonoan-Dandan, Virginia 3Hong Kong and the ...
Edwards, George, 1959-, Byrnes, Andrew
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2018 This article describes the Spanish-language translation and cross-cultural validation of two scales – Human Rights Engagement in Social Work and Human Rights Exposure in Social Work.
McPherson, Jane +5 more
core +1 more source